Phytochemical constituent and subchronic toxicity evaluation of ethanol extract of Saurauia vulcani Korth Lour. Leaves in wistar rats

• Main Authors: Pertiwi, D. (Author), Rosidah (Author), Satria, D. (Author), Simanjuntak, N.J.P (Author), Widjaja, S.S (Author), Yuandani (Author)
• Format: Article
• Language: English
• Published: Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma 2021
• Subjects: Ethanol Extract Saurauia vulcani; Macroscopic; Microscopic; Subchronic toxicity
• Online Access: View Fulltext in Publisher

 The objective of this study is to determine phytochemical constituents and to evaluate the subchronic toxic effect in the ethanol extract of Saurauia vulcani leaves. Phytochemical screening revealed that the extract consists of flavonoids, tannins, glycosides, saponins and steroids/triterpenoids. The extract was orally administered to the rats at doses of 50, 250, 500, 1000 mg/kg body weight (BW) for 90 days. Signs of toxicity and mortality were observed for 90 days and 118 days. The biochemistry, hematology, macro pathology, relative organ weight and histopathology examination were also performed. The macroscopic and microscopic examinations of liver, lung, kidney, spleen and heart showed normal color and texture after treatment with ethanol extract of Saurauia vulcani leaves at doses of 50, 250, 500 and 1000 mg/kg BW. There was no effect on hematological parameters at all doses of the extract. It can be concluded that ethanol extract of Saurauia vulcani leaf is nontoxic at doses 50, 250, 500 and 1000 mg/kg BW for long-term use. © 2021, Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma. All rights reserved.