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10.31788-RJC.2021.1436369 |
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|a 09741496 (ISSN)
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|a Development and validation of ftir spectrophotometry to identify and determine chloramphenicol in marketed capsules
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|b Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma
|c 2021
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|z View Fulltext in Publisher
|u https://doi.org/10.31788/RJC.2021.1436369
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|a Chloramphenicol is an antibiotic compound that inhibits bacterial protein synthesis. All pharmaceutics in the form of finished goods and raw materials must meet the requirements of Indonesian Pharmacopoeia or other standard books. The objectives of this study were to develop and validate a simple and fast analytic method by Fourier Transform Infrared (FTIR) spectrophotometry that allows for qualitative and quantitative analysis of chloramphenicol levels in capsule preparations. Chloramphenicol levels were determined by FTIR analysis using methanol solvents with 0.1 mm slit in the wavenumber range 4000 cm-1 to 650 cm-1. The specific wavenumbers of chloramphenicol solution in methanol were 1695.9 cm–1, 1526.3 cm–1, and 1351.2 cm–1 . Peak height analysis was not significantly different from peak area analysis, and all samples analyzed fulfilled the requirements of the Indonesian Pharmacopoeia, 6th Edition (2020). Analytical validation met requirements for accuracy, precision, linearity, the limit of detection, the limit of quantitation, range, and specificity. The study concludes that identification and determination of chloramphenicol can be conducted by FTIR with simple preparation and fast results. © 2021, Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma. All rights reserved.
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|a 2021
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|a Chloramphenicol RASĀYAN J. Chem
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|a Determination
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|a Development
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|a Fourier Transform Infrared (FTIR)
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|a Identification
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|a No.3
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|a Validation
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|a Vol. 14
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|a Bakri, T.K.
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|a Margata, L.
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|a Nasution, M.A.
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|a Nerdy, N.
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|a Putra, E.D.L.
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|a Surbakti, C.I.
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|t Rasayan Journal of Chemistry
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