Influence of Atomoxetine on Relationship Between ADHD Symptoms and Prefrontal Cortex Activity During Task Execution in Adult Patients

Objective: We conducted this non-randomized prospective interventional study to clarify the relationship between improved attention-deficit hyperactivity disorder (ADHD) symptoms and regional brain activity. Methods: Thirty-one adult patients underwent near-infrared spectroscopy examinations during...

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Main Authors: Egawa, J. (Author), Hayashi, T. (Author), Ono, S. (Author), Orime, N. (Author), Someya, T. (Author), Sugai, T. (Author), Sugimoto, A. (Author), Suzuki, Y. (Author), Yoshinaga, K. (Author)
Format: Article
Language:English
Published: Frontiers Media S.A. 2021
Subjects:
Online Access:View Fulltext in Publisher
LEADER 03824nam a2200577Ia 4500
001 10.3389-fnhum.2021.755025
008 220427s2021 CNT 000 0 und d
020 |a 16625161 (ISSN) 
245 1 0 |a Influence of Atomoxetine on Relationship Between ADHD Symptoms and Prefrontal Cortex Activity During Task Execution in Adult Patients 
260 0 |b Frontiers Media S.A.  |c 2021 
856 |z View Fulltext in Publisher  |u https://doi.org/10.3389/fnhum.2021.755025 
520 3 |a Objective: We conducted this non-randomized prospective interventional study to clarify the relationship between improved attention-deficit hyperactivity disorder (ADHD) symptoms and regional brain activity. Methods: Thirty-one adult patients underwent near-infrared spectroscopy examinations during a go/no-go task, both before and 8 weeks after atomoxetine administration. Results: Clinical symptoms, neuropsychological results of the go/no-go task, and bilateral lateral prefrontal activity significantly changed. A positive correlation was observed between right dorsolateral prefrontal cortex activity and Conners’ Adult ADHD Rating Scales scores. Before atomoxetine administration, no correlations between prefrontal cortex activity and clinical symptoms were observed in all cases. When participants were divided into atomoxetine-responder and non-responder groups, a positive correlation was observed between prefrontal cortex activity and clinical symptoms in the non-responder group before treatment but not in the responder group, suggesting that non-responders can activate the prefrontal cortex without atomoxetine. Conclusions: Individuals with increased ADHD symptoms appear to recruit the right dorsolateral prefrontal cortex more strongly to perform the same task than those with fewer symptoms. In clinical settings, individuals with severe symptoms are often observed to perform more difficultly when performing the tasks which individuals with mild symptoms can perform easily. The atomoxetine-responder group was unable to properly activate the right dorsolateral prefrontal cortex when necessary, and the oral administration of atomoxetine enabled these patients to activate this region. In brain imaging studies of heterogeneous syndromes such as ADHD, the analytical strategy used in this study, involving drug-responsivity grouping, may effectively increase the signal-to-noise ratio. Copyright © 2021 Sugimoto, Suzuki, Yoshinaga, Orime, Hayashi, Egawa, Ono, Sugai and Someya. 
650 0 4 |a adult 
650 0 4 |a aging 
650 0 4 |a Article 
650 0 4 |a atomoxetine 
650 0 4 |a atomoxetine 
650 0 4 |a attention deficit hyperactivity disorder 
650 0 4 |a attention-deficit/hyperactivity disorder 
650 0 4 |a clinical article 
650 0 4 |a Conners adult ADHD rating scale 
650 0 4 |a Conners’ adult ADHD rating scales 
650 0 4 |a disease course 
650 0 4 |a disease severity 
650 0 4 |a dorsolateral prefrontal cortex 
650 0 4 |a electroencephalogram 
650 0 4 |a executive function 
650 0 4 |a female 
650 0 4 |a Go No Go task 
650 0 4 |a go/no-go task 
650 0 4 |a human 
650 0 4 |a lateral prefrontal cortex 
650 0 4 |a male 
650 0 4 |a near infrared spectroscopy 
650 0 4 |a near-infrared spectroscopy 
650 0 4 |a neuropsychology 
650 0 4 |a prefrontal cortex 
650 0 4 |a prospective study 
650 0 4 |a responder group 
650 0 4 |a response inhibition task 
650 0 4 |a scoring system 
700 1 |a Egawa, J.  |e author 
700 1 |a Hayashi, T.  |e author 
700 1 |a Ono, S.  |e author 
700 1 |a Orime, N.  |e author 
700 1 |a Someya, T.  |e author 
700 1 |a Sugai, T.  |e author 
700 1 |a Sugimoto, A.  |e author 
700 1 |a Suzuki, Y.  |e author 
700 1 |a Yoshinaga, K.  |e author 
773 |t Frontiers in Human Neuroscience