Genetic and Drug Inhibition of LDH-A: Effects on Murine Gliomas

Genetic and Drug Inhibition of LDH-A: Effects on Murine Gliomas

The effects of the LDH-A depletion via shRNA knockdown on three murine glioma cell lines and corresponding intracranial (i.c.) tumors were studied and compared to pharmacologic (GNE-R-140) inhibition of the LDH enzyme complex, and to shRNA scrambled control (NC) cell lines. The effects of genetic-sh...

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Bibliographic Details
Main Authors: Blasberg, R. (Author), Cohen, I.J (Author), Ko, M. (Author), Maeda, M. (Author), Mane, M.M (Author), Serganova, I. (Author), Shindo, M. (Author), Vemuri, K. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
glioblastoma
GNE-R-140
immunocompetent host animals
lactate
LDH isoenzymes
LDH-A and LDH-B immunohistochemistry
LDH-A shRNA knockdown
RNA se-qence analyses
tumor growth
Online Access:View Fulltext in Publisher

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