The Placental NLRP3 Inflammasome and Its Downstream Targets, Caspase-1 and Interleukin-6, Are Increased in Human Fetal Growth Restriction: Implications for Aberrant Inflammation-Induced Trophoblast Dysfunction

The Placental NLRP3 Inflammasome and Its Downstream Targets, Caspase-1 and Interleukin-6, Are Increased in Human Fetal Growth Restriction: Implications for Aberrant Inflammation-Induced Trophoblast Dysfunction

Fetal growth restriction (FGR) is commonly associated with placental insufficiency and in-flammation. Nonetheless, the role played by inflammasomes in the pathogenesis of FGR is poorly un-derstood. We hypothesised that placental inflammasomes are differentially expressed and contribute to the aberra...

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Bibliographic Details
Main Authors: Alfaidy, N. (Author), Alfian, I. (Author), Chakraborty, A. (Author), Dimitriadis, E. (Author), Kalionis, B. (Author), Lau, R.W.K (Author), Murthi, P. (Author), Ricardo, S.D (Author), Saini, S. (Author), Samuel, C.S (Author), Yong, H.E.J (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
apoptosis
caspase-1
cytokines
fetal growth restriction
inflammasomes
NLRP3
placental function
Online Access:View Fulltext in Publisher

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