TcdB of Clostridioides difficile Mediates RAS-Dependent Necrosis in Epithelial Cells
A Clostridioides difficile infection (CDI) is the most common nosocomial infection world-wide. The main virulence factors of pathogenic C. difficile are TcdA and TcdB, which inhibit small Rho-GTPases. The inhibition of small Rho-GTPases leads to the so-called cytopathic effect, a reor-ganization of...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI
2022
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| Subjects: | |
| Online Access: | View Fulltext in Publisher |