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| LEADER |
01936nam a2200229Ia 4500 |
| 001 |
10.3390-jcm11092441 |
| 008 |
220510s2022 CNT 000 0 und d |
| 020 |
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|a 20770383 (ISSN)
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| 245 |
1 |
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|a Impact of Whole Body Vibration and Zoledronic Acid on Femoral Structure after Ovariectomy: Morphological Evaluation
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| 260 |
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0 |
|b MDPI
|c 2022
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| 856 |
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|z View Fulltext in Publisher
|u https://doi.org/10.3390/jcm11092441
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| 520 |
3 |
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|a Our study aimed to evaluate the effect of whole body vibration (WBV) treatment as an non-pharmacological method of treatment for early osteopenia in ovariectomized female rats. In total, 48 female Wistar rats were assigned to two groups: sham-operated control (SHAM, n = 12) and ovariectomized (n = 36). Four weeks after ovariectomy, the animals were divided into three experimental groups (n = 12 each): ovariectomized (OVX), ovariectomized subjected to whole body vibration with acceleration level of 0.3 g (OVX + WBV), or ovariectomized subjected to i.m. injection of Zoledronic acid at a dose of 0.025 mg/kg (OVX + ZOL). After the 8th and 16th week of treatment n = 6 rats from each group were euthanized and isolated femora were subjected to histological examination of trabecular bone and analysis of the expression of collagen 1 (Col1), osteoprotegerin (OPG), and receptor activator of nuclear factor kappa-Β ligand (RANKL) involved in bone turnover. The obtained results indicated that widespread vibration therapy can provide negative outcomes such as deterioration of trabecular bone histomorphometry. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
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| 650 |
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4 |
|a osteoporosis
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| 650 |
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|a ovariectomy
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| 650 |
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4 |
|a rat model
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| 650 |
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4 |
|a whole body vibration
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| 700 |
1 |
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|a Dobrowolski, P.
|e author
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1 |
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|a Kostyshyn, N.M.
|e author
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|a Muszyński, S.
|e author
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1 |
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|a Świetlicka, I.
|e author
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| 700 |
1 |
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|a Tomaszewska, E.
|e author
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| 773 |
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|t Journal of Clinical Medicine
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