Discovering Tuberosin and Villosol as Potent and Selective Inhibitors of AKT1 for Therapeutic Targeting of Oral Squamous Cell Carcinoma

Discovering Tuberosin and Villosol as Potent and Selective Inhibitors of AKT1 for Therapeutic Targeting of Oral Squamous Cell Carcinoma

Oral squamous cell carcinoma (OSCC) is a major cause of death in developing countries because of high tobacco consumption. RAC-alpha serine-threonine kinase (AKT1) is considered as an attractive drug target because its prolonged activation and overexpression are associated with cancer progression an...

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Bibliographic Details
Main Authors: Adnan, M. (Author), Alharethi, S.H (Author), Al-Soud, W.A (Author), Chaddha, M. (Author), Elasbali, A.M (Author), Hassan, M.I (Author), Jairajpuri, D.S (Author), Khan, M.S (Author), Mohammad, T. (Author), Yadav, D.K (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
AKT1
drug discovery
molecular dynamics simulation
natural compounds
oral squamous cell carcinoma
personalized medicine
virtual screening
Online Access:View Fulltext in Publisher

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