Secondary Metabolites from Hericium erinaceus and Their Anti-Inflammatory Activities
Hericium erinaceus, a culinary and medicinal mushroom, is widely consumed in Asian countries. Chemical investigation on the fruiting bodies of Hericium erinaceus led to the isolation of one new ergostane-type sterol fatty acid ester, erinarol K (1); and eleven known compounds: 5α,8α-epidioxyergosta-...
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Language: | English |
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MDPI
2022
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Online Access: | View Fulltext in Publisher |
LEADER | 02504nam a2200397Ia 4500 | ||
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001 | 10.3390-molecules27072157 | ||
008 | 220425s2022 CNT 000 0 und d | ||
020 | |a 14203049 (ISSN) | ||
245 | 1 | 0 | |a Secondary Metabolites from Hericium erinaceus and Their Anti-Inflammatory Activities |
260 | 0 | |b MDPI |c 2022 | |
856 | |z View Fulltext in Publisher |u https://doi.org/10.3390/molecules27072157 | ||
520 | 3 | |a Hericium erinaceus, a culinary and medicinal mushroom, is widely consumed in Asian countries. Chemical investigation on the fruiting bodies of Hericium erinaceus led to the isolation of one new ergostane-type sterol fatty acid ester, erinarol K (1); and eleven known compounds: 5α,8α-epidioxyergosta-6,22-dien-3β-yl linoleate (2); ethyl linoleate (3); linoleic acid (4); hericene A (5); hericene D (6); hericene E (7); ergosta-4,6,8(14),22-tetraen-3-one (8); hericenone F (9); ergosterol (10); ergosterol peroxide (11); 3β,5α,6α,22E-ergosta-7,22-diene-3,5,6-triol 6-oleate (12). The chemical structures of the compounds were determined by 1D and 2D NMR (nuclear magnetic resonance) spectroscopy, mass spectra, etc. Anti-inflammatory effects of the isolated aromatic compounds (5–7, 9) were evaluated in terms of inhibition of pro-inflammatory mediator (TNF-α, IL-6 and NO) production in lipopolysaccharide (LPS)-stimulated murine RAW 264.7 macrophage cells. The results showed that compounds 5 and 9 exhibited moderate activity against TNF-α (IC50: 78.50 µM and 62.46 µM), IL-6 (IC50: 56.33 µM and 48.50 µM) and NO (IC50: 87.31 µM and 76.16 µM) secretion. These results supply new information about the secondary metabolites of Hericium erinaceus and their anti-inflammatory effects. © 2022 by the authors. Licensee MDPI, Basel, Switzerland. | |
650 | 0 | 4 | |a Agaricales |
650 | 0 | 4 | |a Agaricales |
650 | 0 | 4 | |a animal |
650 | 0 | 4 | |a Animals |
650 | 0 | 4 | |a anti-inflammatory activity |
650 | 0 | 4 | |a antiinflammatory agent |
650 | 0 | 4 | |a Anti-Inflammatory Agents |
650 | 0 | 4 | |a chemistry |
650 | 0 | 4 | |a Hericium |
650 | 0 | 4 | |a Hericium |
650 | 0 | 4 | |a Hericium erinaceus |
650 | 0 | 4 | |a interleukin 6 |
650 | 0 | 4 | |a Interleukin-6 |
650 | 0 | 4 | |a isolation and structural elucidation |
650 | 0 | 4 | |a Mice |
650 | 0 | 4 | |a mouse |
650 | 0 | 4 | |a secondary metabolites |
650 | 0 | 4 | |a tumor necrosis factor |
650 | 0 | 4 | |a Tumor Necrosis Factor-alpha |
700 | 1 | |a Tang, L. |e author | |
700 | 1 | |a Xie, G. |e author | |
700 | 1 | |a Xie, L. |e author | |
700 | 1 | |a Xie, Y. |e author | |
773 | |t Molecules |