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10.3390-molecules27072166 |
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|a 14203049 (ISSN)
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|a New Organic Salt from Levofloxacin-Citric Acid: What Is the Impact on the Stability and Antibiotic Potency?
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|b MDPI
|c 2022
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|z View Fulltext in Publisher
|u https://doi.org/10.3390/molecules27072166
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|a This research dealt with the composition, structure determination, stability, and antibiotic potency of a novel organic salt composed of levofloxacin (LF) and citric acid (CA), named levofloxacin-citrate (LC). After a stoichiometric proportion screening, the antibiotic-antioxidant reaction was conducted by slow and fast evaporation methods. A series of characterizations using thermal analysis, powder X-ray diffractometry, vibrational spectroscopy, and nuclear magnetic resonance confirmed LC formation. The new organic salt showed a distinct thermogram and diffractogram. Next, Fourier transform infrared indicated the change in N-methylamine and carboxylic stretching, confirmed by1H nuclear magnetic resonance spectra to elucidate the 2D structure. Finally, single-crystal diffractometry determined LC as a new salt structure three-dimensionally. The attributive improvements were demonstrated on the stability toward the humidity and lighting of LC compared to LF alone. Moreover, the antibiotic potency of LF against Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative) enhanced ~1.5–2-fold by LC. Hereafter, LC is a potential salt antibiotic-antioxidant combination for dosage formulas development. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
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|a Anti-Bacterial Agents
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|a antibiotic potency
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|a antiinfective agent
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|a antioxidant
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|a Antioxidants
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|a chemistry
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|a citric acid
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|a citric acid
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|a Citric Acid
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|a infrared spectroscopy
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|a levofloxacin
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|a levofloxacin
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|a Levofloxacin
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|a levofloxacin-citrate
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|a organic salt
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|a Spectroscopy, Fourier Transform Infrared
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|a stability
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|a Laksana, A.N.
|e author
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|a Nugrahani, I.
|e author
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|a Oyama, H.
|e author
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|a Uekusa, H.
|e author
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|t Molecules
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