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03359nam a2200661Ia 4500 |
| 001 |
10.3390-molecules27072176 |
| 008 |
220425s2022 CNT 000 0 und d |
| 020 |
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|a 14203049 (ISSN)
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| 245 |
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|a 5-Bromo-3,4-dihydroxybenzaldehyde Promotes Hair Growth through Activation of Wnt/β-Catenin and Autophagy Pathways and Inhibition of TGF-β Pathways in Dermal Papilla Cells
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| 260 |
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|b MDPI
|c 2022
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| 856 |
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|z View Fulltext in Publisher
|u https://doi.org/10.3390/molecules27072176
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|a Various studies addressing the increasing problem of hair loss, using natural products with few side effects, have been conducted. 5-bromo-3,4-dihydroxybenzaldehyde (BDB) exhibited anti-inflammatory effects in mouse models of atopic dermatitis and inhibited UVB-induced oxidative stress in keratinocytes. Here, we investigated its stimulating effect and the underlying mechanism of action on hair growth using rat vibrissa follicles and dermal papilla cells (DPCs), required for the regulation of hair cycle and length. BDB increased the length of hair fibers in rat vibrissa follicles and the proliferation of DPCs, along with causing changes in the levels of cell cycle-related proteins. We investigated whether BDB could trigger anagen-activating signaling pathways, such as the Wnt/β-catenin pathway and autophagy in DPCs. BDB induces activation of the Wnt/β-catenin pathway through the phosphorylation of GSG3β and β-catenin. BDB increased the levels of autophagic vacuoles and autophagy regulatory proteins Atg7, Atg5, Atg16L, and LC3B. We also investigated whether BDB inhibits the TGF-β pathway, which promotes transition to the catagen phase. BDB inhibited the phosphorylation of Smad2 induced by TGF-β1. Thus, BDB can promote hair growth by modulating anagen signaling by activating Wnt/β-catenin and autophagy pathways and inhibiting the TGF-β pathway in DPCs. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
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|a 5-bromo-3,4-dihydroxybenzaldehyde
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|a 5-bromo-3,4-dihydroxybenzaldehyde
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|a animal
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|a Animals
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|a autophagy
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|a autophagy
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|a Autophagy
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| 650 |
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|a benzaldehyde derivative
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| 650 |
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|a Benzaldehydes
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|a beta catenin
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|a beta Catenin
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|a cell culture
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|a cell cycle protein
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|a Cell Cycle Proteins
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|a cell proliferation
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|a Cell Proliferation
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|a Cells, Cultured
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|a dermal papilla cells
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|a hair
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|a Hair
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|a hair follicle
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| 650 |
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|a Hair Follicle
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|a hair growth
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|a metabolism
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|a Mice
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|a mouse
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|a proliferation
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|a rat
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|a Rats
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|a TGF-β
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|a transforming growth factor beta
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| 650 |
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|a Transforming Growth Factor beta
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| 650 |
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|a Wnt signaling
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| 650 |
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|a Wnt Signaling Pathway
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| 650 |
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|a Wnt/β-catenin
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| 700 |
1 |
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|a Choi, Y.K.
|e author
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|a Han, S.-C.
|e author
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|a Hyun, J.W.
|e author
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1 |
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|a Kang, H.-K.
|e author
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|a Kang, J.-H.
|e author
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| 700 |
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|a Kang, J.-I.
|e author
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1 |
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|a Koh, Y.S.
|e author
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1 |
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|a Lee, G.
|e author
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|a Nam, H.
|e author
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| 700 |
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|a Yoo, E.-S.
|e author
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| 773 |
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|t Molecules
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