CYP11A1‑derived vitamin D hydroxyderivatives as candidates for therapy of basal and squamous cell carcinomas

CYP11A1‑derived vitamin D hydroxyderivatives as candidates for therapy of basal and squamous cell carcinomas

Hydroxyderivatives of vitamin D3, including classical 1,25(OH)2D3 and novel CYP11A1‑derived hydroxyderivatives, exert their biological activity by acting as agonists on the vitamin D receptor (VDR) and inverse agonists on retinoid‑related orphan receptors (ROR)α and γ. The anticancer activities of C...

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Main Authors: Athar, M. (Author), Brożyna, A.A (Author), Elmets, C. (Author), Elsayed, M.M (Author), Janjetovic, Z. (Author), Jetten, A.M (Author), Kim, T.-K (Author), Li, C. (Author), Li, W. (Author), Oak, A.S.W (Author), Podgorska, E. (Author), Qayyum, S. (Author), Slominski, A.T (Author), Slominski, R.M (Author), Tang, E.K.Y (Author), Tuckey, R.C (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
basal cell carcinoma
keratinocytes
retinoid‑­related orphan receptor α
retinoid‑related orphan receptor γ
squamous cell carcinoma
vitamin D
vitamin D receptor
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