The analysis of matrix metalloproteinase-8 in gingival crevicular fluid and periodontal diseases

Background: Periodontal disease, also generally called periodontitis or gum disease, is a chronic infection-induced inflammatory disease that causes tooth loss if not properly treated, and is considered as a modifying factor in systemic health. Gingival crevicular fluid (GCF) matrix metalloproteinas...

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Bibliographic Details
Main Authors: Darwin, E. (Author), Kasuma, N. (Author), Oenzil, F. (Author), Sofyan, Y. (Author)
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2018
Subjects:
Online Access:View Fulltext in Publisher
LEADER 03385nam a2200469Ia 4500
001 10.4103-ijdr.IJDR_97_15
008 220706s2018 CNT 000 0 und d
020 |a 09709290 (ISSN) 
245 1 0 |a The analysis of matrix metalloproteinase-8 in gingival crevicular fluid and periodontal diseases 
260 0 |b Wolters Kluwer Medknow Publications  |c 2018 
856 |z View Fulltext in Publisher  |u https://doi.org/10.4103/ijdr.IJDR_97_15 
520 3 |a Background: Periodontal disease, also generally called periodontitis or gum disease, is a chronic infection-induced inflammatory disease that causes tooth loss if not properly treated, and is considered as a modifying factor in systemic health. Gingival crevicular fluid (GCF) matrix metalloproteinase-8 (MMP-8) is an inflammatory marker found in periodontal pathologic conditions. Gingivitis, a nondestructive type of periodontal disease, can progress to periodontitis if left untreated. Therefore, assessing the level of MMP-8 with comfortable methods and no tissue intervention can determine the progression of the periodontal disease for a better treatment. Objective: The purpose of the present study is to determine the relationship between MMP-8 in GCF and periodontal disease. Setting and Design: This is a cross-sectional study that took place in West Sumatra, Indonesia from June to December 2013. Materials and Methods: This study involves 60 respondents who are divided into three groups based on the periodontal disease index. The samples consist of 20 healthy individuals, 20 with mild gingivitis, and 20 periodontitis initial. GCF was collected from each group. MMP8 level in GCF was tested by using ELISA technique. Statistical Analysis: Data were analyzed with SPSS version 17 Software. ANOVA test was used to determine the differences in average levels of MMP-8. Bonferroni post hoc test was used to discover which spesific means differed. Results: The level of MMP-8 is significantly different between the healthy group and mild gingivitis group, between the healthy group with mild periodontitis group, and also between groups with mild gingivitis and mild periodontitis (P < 0.05). Conclusion: The findings of this study can be used by practitioners of dentistry to establish a proper diagnosis and appropriate treatment of periodontal disease by measuring the scale of MMP-8, to prevent or to minimize further complication in periodontitis patients. © 2018 Indian Journal of Dental Research. 
650 0 4 |a adolescent 
650 0 4 |a Adolescent 
650 0 4 |a adult 
650 0 4 |a Adult 
650 0 4 |a biological marker 
650 0 4 |a Biomarkers 
650 0 4 |a Cross-Sectional Studies 
650 0 4 |a cross-sectional study 
650 0 4 |a enzymology 
650 0 4 |a female 
650 0 4 |a Female 
650 0 4 |a gingival crevicular fluid 
650 0 4 |a Gingival Crevicular Fluid 
650 0 4 |a gingivitis 
650 0 4 |a human 
650 0 4 |a Humans 
650 0 4 |a male 
650 0 4 |a Male 
650 0 4 |a Matrix Metalloproteinase 8 
650 0 4 |a Matrix metalloproteinase-8 
650 0 4 |a neutrophil collagenase 
650 0 4 |a periodontal disease 
650 0 4 |a Periodontal Diseases 
650 0 4 |a young adult 
650 0 4 |a Young Adult 
700 1 |a Darwin, E.  |e author 
700 1 |a Kasuma, N.  |e author 
700 1 |a Oenzil, F.  |e author 
700 1 |a Sofyan, Y.  |e author 
773 |t Indian Journal of Dental Research