Epstein-barr virus is not detected in mucosal lichen planus

• Main Authors: Danielsson, K. (Author), Ebrahimi, M. (Author), Nylander, E. (Author), Sjöström, M. (Author)
• Format: Article
• Language: English
• Published: Medicina Oral S.L. 2018
• Subjects: adult; Adult; aged; Aged; Aged, 80 and over; Article; B lymphocyte; biopsy; controlled study; EBER1 gene; EBER2 gene; Epstein Barr virus; Epstein Barr virus infection; Epstein-barr virus; female; Female; gene; gene expression; Herpesvirus 4, Human; histology; human; human tissue; Humans; in situ hybridization; isolation and purification; lichen planus; Lichen Planus; major clinical study; male; Male; middle aged; Middle Aged; mRNA expression level; mucosa; Mucosal lichen planus; Mucous Membrane; very elderly; virology; young adult; Young Adult
• Online Access: View Fulltext in Publisher

 Background: Lichen planus (LP) is a chronic inflammatory, immunological, mucocutaneous disease can affect skin, genital and oral mucosa. Oral lichen planus (OLP) is the most common noninfectious, chronic inflammatory oral disease affecting 1-2% of the general adult population. World Health Organization (WHO) classifies OLP as a potentially malignant disorder. Epstein Barr virus or human herpesvirus-4, is a member of the herpes virus family and one of the most ubiquitous viruses known to human, infecting approximately 90% of the world’s adult population. The virus often infects B lymphocytes resulting in a wide spectrum of mucocutaneous and systemic diseases, ranging from mild lesions to aggressive malignancies. The aim of this study was to investigate expression of the EBV encoded RNAs EBER1 and EBER2 in oral and genital lichen planus and compare results with normal tissues in situ hybridization which is considered the golden standard for detection of EBER. Material and Methods: A total of 68 biopsies, 25 oral LP, 26 genital LP, 10 oral controls and finally 7 genital controls were analysed using situ hybridization. Result: All samples had RNA as shown by the control slide, whereas no case contained neither EBER1 nor EBER2. Conclusions: Based on results from our study EBV is not involved in aetiology of lichen planus. © Medicina Oral S. L. C.I.F.