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10.5005-jp-journals-10024-2421 |
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220706s2018 CNT 000 0 und d |
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|a 15263711 (ISSN)
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|a Clinical impact and cosmetic acceptability of chlorhexidineenriched toothpaste and mouthwash application on periodontal disease: A randomized clinical study
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|b Jaypee Brothers Medical Publishers (P) Ltd
|c 2018
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|z View Fulltext in Publisher
|u https://doi.org/10.5005/jp-journals-10024-2421
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|a Aims: Oral hygiene is key to prevent periodontal disease (PD). The efficacy of chlorhexidine-containing products has been largely proven, often being tooth discoloration an unwanted associated side-effect. Importantly, some differences related to the pharmaceutical presentation of these products have also been reported. This study aimed to evaluate the efficacy of two different pharmaceutical forms [toothpaste (TP) and mouthwash (MW)] of a new product containing chlorhexidine, dexpanthenol, allantoin and bioadhesive excipient (CDAB) (Bexident® Gums Coadjuvant Treatment) on volunteers with PD. Their preferences, acceptability and cosmetic properties, as well as tooth discoloration, were also assessed. Materials and methods: Total 60 subjects showing mildmoderate symptoms of gingivitis were randomly assigned to two different groups: one receiving TP (n = 30) and the other one receiving MW (n = 30). Periodontal disease index (PDI) was used to evaluate clinical signs at baseline (T0) and after 21 days (T21) of daily use of the products. Satisfaction was assessed through the affirmative/negative answers obtained with the visual analog scale (VAS). Results: All participants completed the study. A significant improvement of PDI score after treatment was reported in both groups (T21/T0) (p < 0.001). Thus, gingivitis improved from moderate to negative [increase = 20.0% (TP)/36.7% (MW)] and from mild to negative [increase = 56.7% (TP)/50.0% (MW)]. After treatment, all subjects reported to have healthier and/or less bleeding teeth (TP 9.0/9.4; MW 8.0/8.2) and would recommend the product (TP:100%/MW:96.6%) with no specific preference regarding its presentation. No change of teeth color was observed. Conclusion: Subjects with PD who received oral care with a new formulation of either chlorhexidine-containing TP or MW for 21 days, reported a significant improvement of their symptoms and resolution of the gingivitis with no associated tooth discoloration. Patients did not show a specific preference for any of the pharmaceutical presentations. Clinical significance: This new formulation of a chlorhexidinecontaining product in both TP and MW forms resulted effective for PD treatment and well accepted by the patients. © Jaypee Brothers Medical Publishers (P) Ltd.
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|a adolescent
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|a Adolescent
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|a adult
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|a Adult
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|a aged
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|a Aged
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|a Allantoin
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|a chemistry
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|a chlorhexidine
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|a Chlorhexidine
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|a controlled study
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|a Dexpanthenol
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|a female
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|a Female
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|a gingivitis
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|a Gingivitis
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|a human
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|a Humans
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|a male
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|a Male
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|a middle aged
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|a Middle Aged
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|a mouthwash
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|a Mouthwash
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|a Mouthwashes
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|a patient satisfaction
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|a Patient Satisfaction
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|a periodontal disease
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|a Periodontal Diseases
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|a Periodontal-disease-index
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|a psychology
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|a randomized controlled trial
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|a tooth discoloration
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|a Tooth Discoloration
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|a toothpaste
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|a Toothpaste
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|a Toothpastes
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|a treatment outcome
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|a Treatment Outcome
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|a young adult
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|a Young Adult
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|a Garre, A.
|e author
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|a Llovera, B.F.
|e author
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|a Magaz, V.R.
|e author
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|a Martí, M.
|e author
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|t Journal of Contemporary Dental Practice
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