Clinical assessment and cytokines level in constipation-predominant irritable bowel syndrome participants treated with Lactobacillus-containing cultured milk drink
Background: Gut dysbiosis is linked with the pathophysiology of irritable bowel syndrome (IBS). Manipulation of intestinal microbiota using cultured milk drinks may stimulate the immune system, hence providing beneficial support in IBS treatment. This study aimed to investigate the effects of cultur...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universa Press
2021
|
| Series: | Acta Gastro-Enterologica Belgica
|
| Subjects: | |
| Online Access: | View Fulltext in Publisher View in Scopus |
| LEADER | 02599nam a2200277Ia 4500 | ||
|---|---|---|---|
| 001 | 10.51821-84.4.009 | ||
| 008 | 220121s2021 CNT 000 0 und d | ||
| 020 | |a 17843227 (ISSN) | ||
| 245 | 1 | 0 | |a Clinical assessment and cytokines level in constipation-predominant irritable bowel syndrome participants treated with Lactobacillus-containing cultured milk drink |
| 260 | 0 | |b Universa Press |c 2021 | |
| 490 | 1 | |a Acta Gastro-Enterologica Belgica | |
| 650 | 0 | 4 | |a Cultured milk products |
| 650 | 0 | 4 | |a IL-6 |
| 650 | 0 | 4 | |a IL-8 |
| 650 | 0 | 4 | |a Irritable bowel syndrome |
| 650 | 0 | 4 | |a TNF-alpha |
| 856 | |z View Fulltext in Publisher |u https://doi.org/10.51821/84.4.009 | ||
| 856 | |z View in Scopus |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122228054&doi=10.51821%2f84.4.009&partnerID=40&md5=73f78d0280586d9a67d259b6ff1218c2 | ||
| 520 | 3 | |a Background: Gut dysbiosis is linked with the pathophysiology of irritable bowel syndrome (IBS). Manipulation of intestinal microbiota using cultured milk drinks may stimulate the immune system, hence providing beneficial support in IBS treatment. This study aimed to investigate the effects of cultured milk drink on clinical symptoms, intestinal transit time (ITT), fecal pH and cytokines in constipation-predominant IBS (IBS-C) as compared to non-IBS participants. Methods: Each recruited participant was given three bottles of 125 ml cultured milk drink containing 109 cfu Lactobacillus acidophilus LA-5 and Lactobacillus paracasei L. CASEI-01 consumed daily for 30 days. At pre-and post-30-day consumption, fecal pH, ITT, clinical symptoms, IL-6, IL-8 and TNF-α levels were assessed. Seventy-seven IBS-C and 88 non-IBS were enrolled. Results: Post-consumption, 97.4% of IBS-C experienced improvements in constipation-related symptoms supported by the significant reduction of ITT and decreased fecal pH (p<0.05). All pro-inflammatory cytokines were significantly lower in post as compared to pre-consumption of cultured milk drinks in IBS-C (p<0.05). There was significant reduction in the IL-8 and TNF-α levels in post-as compared to pre-consumption for the non-IBS (p < 0.05). Conclusion: Cultured milk drink taken daily improved clinical symptoms and reduced cytokines, hence should be considered as an adjunctive treatment in IBS-C individuals. © 2021, Universa Press. All rights reserved. | |
| 700 | 1 | 0 | |a Abdul Rani, R. |e author |
| 700 | 1 | 0 | |a Alfian, E. |e author |
| 700 | 1 | 0 | |a Jaafar, N.Md. |e author |
| 700 | 1 | 0 | |a Mohd Rathi, N.D. |e author |
| 700 | 1 | 0 | |a Mokhtar, N.M. |e author |
| 700 | 1 | 0 | |a Raja Ali, R.A. |e author |
| 773 | |t Acta Gastro-Enterologica Belgica | ||