Sperm DNA fragmentation: A new guideline for clinicians
Sperm DNA integrity is crucial for fertilization and development of healthy offspring. The spermatozoon undergoes extensive molecular remodeling of its nucleus during later phases of spermatogenesis, which imparts compaction and protects the genetic content. Testicular (defective maturation and abor...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Korean Society for Sexual Medicine and Andrology,
2020
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| Subjects: | |
| Online Access: | View Fulltext in Publisher View in Scopus |
| LEADER | 04614nam a2201033Ia 4500 | ||
|---|---|---|---|
| 001 | 10.5534-WJMH.200128 | ||
| 008 | 220121s2020 CNT 000 0 und d | ||
| 020 | |a 22874208 (ISSN) | ||
| 245 | 1 | 0 | |a Sperm DNA fragmentation: A new guideline for clinicians |
| 260 | 0 | |b Korean Society for Sexual Medicine and Andrology, |c 2020 | |
| 650 | 0 | 4 | |a adult |
| 650 | 0 | 4 | |a antioxidant |
| 650 | 0 | 4 | |a ascorbic acid |
| 650 | 0 | 4 | |a Assisted reproductive techniques outcome |
| 650 | 0 | 4 | |a body mass |
| 650 | 0 | 4 | |a carnitine |
| 650 | 0 | 4 | |a case report |
| 650 | 0 | 4 | |a clinical article |
| 650 | 0 | 4 | |a Clinical guidelines |
| 650 | 0 | 4 | |a comparative study |
| 650 | 0 | 4 | |a conception |
| 650 | 0 | 4 | |a DNA fragmentation |
| 650 | 0 | 4 | |a DNA strand breakage |
| 650 | 0 | 4 | |a epididymis |
| 650 | 0 | 4 | |a folic acid |
| 650 | 0 | 4 | |a follow up |
| 650 | 0 | 4 | |a high risk patient |
| 650 | 0 | 4 | |a human |
| 650 | 0 | 4 | |a Infertility |
| 650 | 0 | 4 | |a infertility therapy |
| 650 | 0 | 4 | |a inflammation |
| 650 | 0 | 4 | |a intracytoplasmic sperm injection |
| 650 | 0 | 4 | |a lifestyle modification |
| 650 | 0 | 4 | |a luteinizing hormone |
| 650 | 0 | 4 | |a luteinizing hormone blood level |
| 650 | 0 | 4 | |a male |
| 650 | 0 | 4 | |a Male |
| 650 | 0 | 4 | |a male infertility |
| 650 | 0 | 4 | |a microsurgery |
| 650 | 0 | 4 | |a Oxidative stress |
| 650 | 0 | 4 | |a parthenogenesis |
| 650 | 0 | 4 | |a physical examination |
| 650 | 0 | 4 | |a practice guideline |
| 650 | 0 | 4 | |a recurrent abortion |
| 650 | 0 | 4 | |a Review |
| 650 | 0 | 4 | |a risk factor |
| 650 | 0 | 4 | |a selenium |
| 650 | 0 | 4 | |a semen analysis |
| 650 | 0 | 4 | |a sperm |
| 650 | 0 | 4 | |a Sperm DNA fragmentation |
| 650 | 0 | 4 | |a spermatozoon count |
| 650 | 0 | 4 | |a spermatozoon density |
| 650 | 0 | 4 | |a testicular sperm aspiration |
| 650 | 0 | 4 | |a testis |
| 650 | 0 | 4 | |a testosterone |
| 650 | 0 | 4 | |a testosterone blood level |
| 650 | 0 | 4 | |a treatment outcome |
| 650 | 0 | 4 | |a ubidecarenone |
| 650 | 0 | 4 | |a varicocele |
| 650 | 0 | 4 | |a varicocelectomy |
| 650 | 0 | 4 | |a zinc |
| 856 | |z View Fulltext in Publisher |u https://doi.org/10.5534/WJMH.200128 | ||
| 856 | |z View in Scopus |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-85093687092&doi=10.5534%2fWJMH.200128&partnerID=40&md5=08d6fa518a1ed12102f3c8a82deea806 | ||
| 520 | 3 | |a Sperm DNA integrity is crucial for fertilization and development of healthy offspring. The spermatozoon undergoes extensive molecular remodeling of its nucleus during later phases of spermatogenesis, which imparts compaction and protects the genetic content. Testicular (defective maturation and abortive apoptosis) and post-testicular (oxidative stress) mechanisms are implicated in the etiology of sperm DNA fragmentation (SDF), which affects both natural and assisted reproduction. Several clinical and environmental factors are known to negatively impact sperm DNA integrity. An increasing number of reports emphasizes the direct relationship between sperm DNA damage and male infertility. Currently, several assays are available to assess sperm DNA damage, however, routine assessment of SDF in clinical practice is not recommended by professional organizations. This article provides an overview of SDF types, origin and comparative analysis of various SDF assays while primarily focusing on the clinical indications of SDF testing. Importantly, we report four clinical cases where SDF testing had played a significant role in improving fertility outcome. In light of these clinical case reports and recent scientific evidence, this review provides expert recommendations on SDF testing and examines the advantages and drawbacks of the clinical utility of SDF testing using Strength-Weaknesses-Opportunities-Threats (SWOT) analysis. Copyright © 2020 Korean Society for Sexual Medicine and Andrology | |
| 700 | 1 | 0 | |a Agarwal, A. |e author |
| 700 | 1 | 0 | |a Alves, M.G. |e author |
| 700 | 1 | 0 | |a Ambar, R. |e author |
| 700 | 1 | 0 | |a Arafa, M. |e author |
| 700 | 1 | 0 | |a Barbarosie, C. |e author |
| 700 | 1 | 0 | |a Baskaran, S. |e author |
| 700 | 1 | 0 | |a Cho, C.L. |e author |
| 700 | 1 | 0 | |a Durairajanayagam, D. |e author |
| 700 | 1 | 0 | |a Finelli, R. |e author |
| 700 | 1 | 0 | |a Henkel, R. |e author |
| 700 | 1 | 0 | |a Iovine, C. |e author |
| 700 | 1 | 0 | |a Jindal, S. |e author |
| 700 | 1 | 0 | |a Kavoussi, P. |e author |
| 700 | 1 | 0 | |a Ko, E. |e author |
| 700 | 1 | 0 | |a Kuchakulla, M. |e author |
| 700 | 1 | 0 | |a Leisegang, K. |e author |
| 700 | 1 | 0 | |a Majzoub, A. |e author |
| 700 | 1 | 0 | |a Parekh, N. |e author |
| 700 | 1 | 0 | |a Ramasamy, R. |e author |
| 700 | 1 | 0 | |a Robert, K.A. |e author |
| 700 | 1 | 0 | |a Selvam, M.K.P. |e author |
| 700 | 1 | 0 | |a Sengupta, P. |e author |
| 700 | 1 | 0 | |a Shah, R. |e author |
| 700 | 1 | 0 | |a Tadros, N. |e author |
| 773 | |t World Journal of Men's Health |x 22874208 (ISSN) |g 38 | ||