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01161 am a22001333u 4500 |
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145817 |
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|a Ruhl, Thomas
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|a Stulz, Eugen
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|a Synthesis of new building blocks for use in supramolecular DNA architectures
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|c 2010-02-02.
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|z Get fulltext
|u https://eprints.soton.ac.uk/145817/1/SupramolChem_10.pdf
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|a New nucleoside building blocks for the synthesis of functional DNA are presented. A porphyrin-bis nucleoside dU-porphyrin-dU was synthesised from a di-acetylene-substituted porphyrin using Sonogashira coupling with 5-iodo deoxy uridine. The same strategy was used to obtain a new terpy-functionalised nucleoside dUterpy. This building block can be metallated with ruthenium(II) either to make a mono-nucleoside ruthenium complex (dUterpy)RuII(terpy), or to connect two building blocks to create a bis-nucleoside (dUterpy)2RuII. The terpy nucleoside building block dUterpy was incorporated into short strands of DNA to give TXT, TXXT and TXXXT as sequences (X = dUterpy). The functionalised DNA has the potential to create supramolecular assemblies through metal complexation
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