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02371 am a22002293u 4500 |
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149043 |
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|a Hogan, Alexandra M.
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|a Virues-Ortega, Javier
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|a Baya Botti, Ana Baya
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|a Bucks, Romola
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|a Holloway, John
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|a Rose-Zerilli, Matthew J.
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|a Palmer, Lyle J.
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|a Webster, Rebecca J.
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|a Baldeweg, Torsten
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|a Kirkham, Fenella J.
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|a Development of aptitude at altitude
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|c 2010-05.
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|z Get fulltext
|u https://eprints.soton.ac.uk/149043/1/__userfiles.soton.ac.uk_Users_nsc_mydesktop_149043kirkham.pdf
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|a Millions of people currently live at altitudes in excess of 2500 metres, where oxygen supply is limited, but very little is known about the development of brain and behavioural function under such hypoxic conditions. We describe the physiological, cognitive and behavioural profile of a large cohort of infants (6-12?months), children (6-10?years) and adolescents (13-16?years) who were born and are living at three altitude locations in Bolivia (?500?m, ?2500?m and ?3700?m). Level of haemoglobin oxygen saturation and end-tidal carbon dioxide were significantly lower in all age groups living above 2500?metres, confirming the presence of hypoxia and hypocapnia, but without any detectable detriment to health. Infant measures of neurodevelopment and behaviour yielded comparable results across altitude groups. Neuropsychological assessment in children and adolescent groups indicated a minor reduction in psychomotor speed with increasing altitude, with no effect of age. This may result from slowing of underlying brain activity in parallel with reduced cerebral metabolism and blood flow, evidenced here by reduced cerebral blood flow velocity, particularly in the basilar artery, in children and adolescents. The proportion of European, Native American and African genetic admixture was comparable across altitude groups, suggesting that adaptation to high altitude in these children occurred in response to chronic hypoxic exposure irrespective of ethnic origin. Thus, psychomotor slowing is proposed to be an adaptive rather than a deficient trait, perhaps enabling accuracy of mental activity in hypoxic conditions.
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