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01918 am a22002053u 4500 |
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|a Pourazar, Jamshid
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|a Frew, Anthony J.
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|a Blomberg, Anders
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|a Helleday, Ragnberth
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|a Kelly, Frank J.
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|a Wilson, Susan
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|a Sandström, Thomas
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|a Diesel exhaust exposure enhances the expression of IL-13 in the bronchial epithelium of healthy subjects
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|c 2004-09.
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|z Get fulltext
|u https://eprints.soton.ac.uk/190919/1/1_s2.0_S0954611104001040_main.pdf
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|a Epidemiological studies have demonstrated adverse health effects of environmental pollution. Diesel exhaust (DE) is an important contributor to ambient particulate matter pollution. DE exposure has been shown to induce a pronounced inflammatory response in the airways, with an enhanced epithelial expression of IL-8, and Gro-alpha in healthy subjects. The present investigation was aimed to further characterise the epithelial response to DE in vivo, with particular reference to possible TH2 response, in non-atopic healthy subjects. To determine this response, 15 healthy, non-atopic non-smoking subjects with normal lung function were exposed to DE (PM10 300 microg/m3) and filtered air during 1 h on two separate randomised occasions. Bronchoscopy sampling of bronchial mucosal biopsies was performed 6 h after exposure. Immunohistochemical staining were performed using mAb for IL-10, IL-13 and IL-18 expression. DE exposure induced a significant increase in the expression of IL-13 in the bronchial epithelium cells, 2.1 (1.35-4.88) Md (Q1-Q3) vs. air 0.94 (0.53-1.23); P = 0.009. No significant changes were seen in IL-10 and IL-18 expression. This finding suggests an TH2-inflammatory response in the airways of non-atopic healthy individuals.
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|a Article
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