Apolipoprotein E genotype, coagulation, and survival following acute stroke

Apolipoprotein E genotype, coagulation, and survival following acute stroke

The authors hypothesized that divergent influences of the APOE ?4 allele on ischemic and hemorrhagic stroke survival might result from differences in coagulation profiles. In 49 hemorrhagic stroke patients, ?4 carriers had higher partial thromboplastin time ratios (p < 0.01) than non-?4 carriers....

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Main Authors: Weir, C.J (Author), McCarron, M.O (Author), Muir, K.W (Author), Dyker, A.G (Author), Bone, I. (Author), Lees, K.R (Author), Nicoll, J.A (Author)
Format: Article
Language:English
Published: 2001-09.
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Online Access:Get fulltext
LEADER 01196 am a22001933u 4500
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042 |a dc 
100 1 0 |a Weir, C.J.  |e author 
700 1 0 |a McCarron, M.O.  |e author 
700 1 0 |a Muir, K.W.  |e author 
700 1 0 |a Dyker, A.G.  |e author 
700 1 0 |a Bone, I.  |e author 
700 1 0 |a Lees, K.R.  |e author 
700 1 0 |a Nicoll, J.A.  |e author 
245 0 0 |a Apolipoprotein E genotype, coagulation, and survival following acute stroke 
260 |c 2001-09. 
856 |z Get fulltext  |u https://eprints.soton.ac.uk/27737/1/00006114-200109250-00034.pdf 
520 |a The authors hypothesized that divergent influences of the APOE ?4 allele on ischemic and hemorrhagic stroke survival might result from differences in coagulation profiles. In 49 hemorrhagic stroke patients, ?4 carriers had higher partial thromboplastin time ratios (p < 0.01) than non-?4 carriers. Among 529 ischemic stroke patients, increasing ?4 allele dose was associated with improved survival (p = 0.03) after adjusting for baseline NIH stroke scale (p = 0.00001) and partial thromboplastin time ratio (p = 0.01). Relative anticoagulation does not fully explain the survival advantage in ?4-carrying ischemic stroke patients. 
655 7 |a Article 

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