Matrix metalloproteinase-1 is regulated in tuberculosis by a p38 MAPK-dependent, p-aminosalicylic acid-sensitive signaling cascade
Mycobacterium tuberculosis (M. tb) must cause lung disease to spread. Matrix metalloproteinases (MMPs) degrade the extracellular matrix and are implicated in tuberculosis-driven tissue destruction. We investigated signaling pathways regulating macrophage MMP-1 and -7 in human pulmonary tuberculosis...
Main Authors: | Rand, Lucinda (Author), Green, Justin A. (Author), Saraiva, Luísa (Author), Friedland, Jon S. (Author), Elkington, Paul T.G (Author) |
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Format: | Article |
Language: | English |
Published: |
2009-05-01.
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Subjects: | |
Online Access: | Get fulltext |
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