Association of Reduced Type IX Collagen Gene Expression in Human Osteoarthritic Chondrocytes With Epigenetic Silencing by DNA Hypermethylation

Association of Reduced Type IX Collagen Gene Expression in Human Osteoarthritic Chondrocytes With Epigenetic Silencing by DNA Hypermethylation

Objective To investigate whether the changes in collagen gene expression in osteoarthritic (OA) human chondrocytes are associated with changes in the DNA methylation status in the COL2A1 enhancer and COL9A1 promoter. Methods Expression levels were determined using quantitative reverse transcripti...

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Bibliographic Details
Main Authors:	Imagawa, Kei (Author), de Andrés, María C. (Author), Hashimoto, Ko (Author), Itoi, Eiji (Author), Otero, Miguel (Author), Roach, Helmtrud I (Author), Goldring, Mary B. (Author), Oreffo, Richard O.C (Author)
Format:	Article
Language:	English
Published:	2014-11.
Subjects:	Article
Online Access:	Get fulltext Get fulltext

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