Profound parental bias associated with chromosome 14 acquired uniparental disomy indicates targeting of an imprinted locus

Acquired uniparental disomy (aUPD) is a common finding in myeloid malignancies and typically acts to convert a somatically-acquired heterozygous mutation to homozygosity. We sought to identify the target of chromosome 14 aUPD (aUPD14), a recurrent abnormality in myeloid neoplasms and population coho...

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Main Authors: Chase, A. (Author), Leung, W. (Author), Tapper, W. (Author), Jones, A.V (Author), Knoops, L. (Author), Rasi, C. (Author), Forsberg, L.A (Author), Guglielmelli, P. (Author), Zoi, K. (Author), Hall, V. (Author), Chiecchio, L. (Author), Eder-Azanza, L. (Author), Bryant, C. (Author), Lannfelt, L. (Author), Docherty, L. (Author), White, H.E (Author), Score, J (Author), Mackay, D.J.G (Author), Vannucchi, A.M (Author), Dumanski, J.P (Author), Cross, N.C.P (Author)
Format: Article
Language:English
Published: 2015-10.
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