Knockdown of c-Myc expression by RNAi inhibits MCF-7 breast tumor cells growth in vitro and in vivo

Knockdown of c-Myc expression by RNAi inhibits MCF-7 breast tumor cells growth in vitro and in vivo

c-Myc has a pivotal function in the development of breast cancer. Our data show that decreasing the c-Myc protein level in MCF-7 cells by RNAi could significantly inhibit tumor growth both in vitro and in vivo, and imply the therapeutic potential of RNAi on the treatment of breast cancer by targetin...

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Bibliographic Details
Main Authors: Wang, Yi-hua (Author), Liu, Shuang (Author), Zhang, Guo (Author), Zhou, Cui-qi (Author), Zhu, Hong-xia (Author), Zhou, Xiao-bo (Author), Quan, Lan-ping (Author), Bai, Jin-feng (Author), Xu, Ning-zhi (Author)
Format: Article
Language:English
Published: 2004-12-17.
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Article
Online Access:Get fulltext
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100 1 0 |a Wang, Yi-hua  |e author 
700 1 0 |a Liu, Shuang  |e author 
700 1 0 |a Zhang, Guo  |e author 
700 1 0 |a Zhou, Cui-qi  |e author 
700 1 0 |a Zhu, Hong-xia  |e author 
700 1 0 |a Zhou, Xiao-bo  |e author 
700 1 0 |a Quan, Lan-ping  |e author 
700 1 0 |a Bai, Jin-feng  |e author 
700 1 0 |a Xu, Ning-zhi  |e author 
245 0 0 |a Knockdown of c-Myc expression by RNAi inhibits MCF-7 breast tumor cells growth in vitro and in vivo 
260 |c 2004-12-17. 
856 |z Get fulltext  |u https://eprints.soton.ac.uk/385923/1/art%25253A10.1186%25252Fbcr975.pdf 
520 |a c-Myc has a pivotal function in the development of breast cancer. Our data show that decreasing the c-Myc protein level in MCF-7 cells by RNAi could significantly inhibit tumor growth both in vitro and in vivo, and imply the therapeutic potential of RNAi on the treatment of breast cancer by targeting overexpression oncogenes such as c-myc, and c-myc might be a potential therapeutic target for human breast cancer. 
540 |a other 
655 7 |a Article 

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