Open-Label Study of Absorption and Clearance of 1% Voriconazole Eye Drops
Twenty participants undergoing elective cataract surgery received 1% voriconazole eye drops (1 drop per eye) either 20, 40, 60, or 80 min before surgery. Median voriconazole concentrations of 1.9 to 3.2 mg/liter in aqueous humor samples were attained over the first 80 min, which were higher than in...
Main Authors: | , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
2016
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Subjects: | |
Online Access: | View Fulltext in Publisher |
Summary: | Twenty participants undergoing elective cataract surgery received 1% voriconazole eye drops (1 drop per eye) either 20, 40, 60, or 80 min before surgery. Median voriconazole concentrations of 1.9 to 3.2 mg/liter in aqueous humor samples were attained over the first 80 min, which were higher than in vitro MIC90 values for typical fungi that cause keratitis. |
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DOI: | 10.1128/AAC.00683-16 |