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01574nam a2200253Ia 4500 |
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10.22146-ijc.39566 |
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220223s2020 CNT 000 0 und d |
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|a New Access to Pyrano[2,3-c]pyrazole-3-carboxylates via Domino Four-Component Reaction and Their Antimicrobial Activity
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|c 2020
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|z View Fulltext in Publisher
|u https://doi.org/10.22146/ijc.39566
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|a A library of some novel classes of pyrano[2,3-c]pyrazole-3-carboxylates was synthesized by employing uncatalyzed domino four-component reaction using diethyloxaloacetate, hydrazine hydrate, aldehydes and malononitrile in refluxing of ethanol-acetic acid solvent systems. Series of domino reactions involving of pyrazolone formation, Michael addition, and Thorpe-Ziegler cyclization reaction managed to produce the cyclized products from moderate to excellent yield. This protocol provides a reliable, general and salient procedure for the title compound using a one-pot approach. Preliminary biological screening unveiled limited potentials of this class of compounds for antimicrobial lead compound due to its limited solubility properties.
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|a ACID
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|a DERIVATIVES
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|a diethyloxaloacetate
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|a four-component reactions
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|a pyrano[2,3-c]pyrazole-3-carboxylate
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|a Isa, MM
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|a Johari, SA
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|a Low, ALM
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|a Maarop, MS
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|a Mohammat, MF
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|a Rashid, FNAA
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|a Shaameri, Z
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| 773 |
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|t INDONESIAN JOURNAL OF CHEMISTRY
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