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02220nam a2200373Ia 4500 |
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10.3390-molecules24061003 |
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|a Bioactive 2-(Methyldithio)Pyridine-3-Carbonitrile from Persian Shallot (Allium stipitatum Regel.) Exerts Broad-Spectrum Antimicrobial Activity
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|c 2019
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|a Allium stipitatum
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|a antibacterial
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|a COSTS
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|a DERIVATIVES
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|a EPIDEMIOLOGY
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|a METHICILLIN-RESISTANT
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|a methicillin-resistant Staphylococcus aureus
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|a minimum inhibitory concentration
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|a MORTALITY
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|a NATURAL-PRODUCTS
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|a OUTCOMES
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|z View Fulltext in Publisher
|u https://doi.org/10.3390/molecules24061003
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|a Antibiotic resistance is a problem that continues to challenge the healthcare sector, especially in clinically significant pathogens like methicillin-resistant Staphylococcus aureus (MRSA). Herein is described the isolation and structure elucidation of a bioactive compound from Allium stipitatum with antimicrobial activity. Crude Allium stipitatum dichloromethane extract (ASDE) was subjected to systematic purification by chromatographic procedures to afford various bioactive fractions. A fraction that exhibited anti-MRSA activity (4 mu gmL(-1)) was further characterized to determine the structure. The structure of the compound was elucidated as 2-(methyldithio)pyridine-3-carbonitrile (2-Medpy-3-CN). The 2-Medpy-3-CN compound, which was screened for antimicrobial activity, exhibited minimum inhibitory concentrations (MICs) in the range of 0.5 to >64 mu gmL(-1) for tested bacterial species and 0.25 to 2 mu gmL(-1) for Candida spp. Further studies are important to confirm the drug target and mechanism of action.
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|a Chigurupati, S
|e author
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|a Fauzi, FM
|e author
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|a Ghaznavi-Rad, E
|e author
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|a Hamat, RA
|e author
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|a Joseph, N
|e author
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|a Karunanidhi, A
|e author
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|a Lung, LTT
|e author
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|a Nathan, JJ
|e author
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|a Neela, V
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|a Pichika, MR
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|a van Belkum, A
|e author
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|t MOLECULES
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