Autocrine TGF-β in Cancer: Review of the Literature and Caveats in Experimental Analysis

by Hendrik Ungefroren
Published 2021-01-01

RAC1B Suppresses TGF-β1-Dependent Cell Migration in Pancreatic Carcinoma Cells through Inhibition of the TGF-β Type I Receptor ALK5

by Hendrik Ungefroren, Hannah Otterbein, Christian Fiedler, Koichiro Mihara, Morley D. Hollenberg, Frank Gieseler, Hendrik Lehnert, David Witte
Published 2019-05-01

Downregulation of TRAIL-Receptor 1 Increases TGFβ Type II Receptor Expression and TGFβ Signalling Via MicroRNA-370-3p in Pancreatic Cancer Cells

by David I. Radke, Qi Ling, Robert Häsler, Gökhan Alp, Hendrik Ungefroren, Anna Trauzold
Published 2018-10-01

Autocrine TGFβ1 Opposes Exogenous TGFβ1-Induced Cell Migration and Growth Arrest through Sustainment of a Feed-Forward Loop Involving MEK-ERK Signaling

by Hendrik Ungefroren, Jessica Christl, Caroline Eiden, Ulrich F. Wellner, Hendrik Lehnert, Jens-Uwe Marquardt
Published 2021-03-01

TGF-β Signaling in Cancer: Control by Negative Regulators and Crosstalk with Proinflammatory and Fibrogenic Pathways

by Hendrik Ungefroren
Published 2019-03-01

The Role of PAR2 in TGF-β1-Induced ERK Activation and Cell Motility

by Hendrik Ungefroren, David Witte, Christian Fiedler, Thomas Gädeken, Roland Kaufmann, Hendrik Lehnert, Frank Gieseler, Bernhard H. Rauch
Published 2017-12-01

Proteinase-Activated Receptor 2 May Drive Cancer Progression by Facilitating TGF-β Signaling

by Hendrik Ungefroren, David Witte, Bernhard H. Rauch, Utz Settmacher, Hendrik Lehnert, Frank Gieseler, Roland Kaufmann
Published 2017-11-01

Proteinase-Activated Receptor 2 Is a Novel Regulator of TGF-β Signaling in Pancreatic Cancer

by David Witte, Franziska Zeeh, Thomas Gädeken, Frank Gieseler, Bernhard H. Rauch, Utz Settmacher, Roland Kaufmann, Hendrik Lehnert, Hendrik Ungefroren
Published 2016-11-01

The role of TGF-β and its crosstalk with RAC1/RAC1b signaling in breast and pancreas carcinoma

by Catharina Melzer, Ralf Hass, Juliane von der Ohe, Hendrik Lehnert, Hendrik Ungefroren
Published 2017-05-01

The Small GTPase RAC1B: A Potent Negative Regulator of-and Useful Tool to Study-TGFβ Signaling

by Hendrik Ungefroren, Ulrich F. Wellner, Tobias Keck, Hendrik Lehnert, Jens-Uwe Marquardt
Published 2020-11-01

Signaling Crosstalk of TGF-β/ALK5 and PAR2/PAR1: A Complex Regulatory Network Controlling Fibrosis and Cancer

by Hendrik Ungefroren, Frank Gieseler, Roland Kaufmann, Utz Settmacher, Hendrik Lehnert, Bernhard H. Rauch
Published 2018-05-01

RAC1B Regulation of <i>TGFB1</i> Reveals an Unexpected Role of Autocrine TGFβ1 in the Suppression of Cell Motility

by Hendrik Ungefroren, Hannah Otterbein, Ulrich F. Wellner, Tobias Keck, Hendrik Lehnert, Jens-Uwe Marquardt
Published 2020-11-01

Characterization of spontaneous and TGF-β-induced cell motility of primary human normal...

by Katharina Mandel, Daniel Seidl, Dirk Rades, Hendrik Lehnert, Frank Gieseler, Ralf Hass, Hendrik Ungefroren
Published 2013-01-01

TGF-β-Dependent Growth Arrest and Cell Migration in Benign and Malignant Breast Epithelial Cells Are Antagonistically Controlled by Rac1 and Rac1b

by Catharina Melzer, Juliane von der Ohe, Ralf Hass, Hendrik Ungefroren
Published 2017-07-01

Correction: Characterization of Spontaneous and TGF-β-Induced Cell Motility of Primary Human Normal...

by Katharina Mandel, Daniel Seidl, Dirk Rades, Hendrik Lehnert, Frank Gieseler, Ralf Hass, Hendrik Ungefroren
Published 2013-01-01

RAC1B Induces SMAD7 via USP26 to Suppress TGFβ1-Dependent Cell Migration in Mesenchymal-Subtype Carcinoma Cells

by Hendrik Ungefroren, Anuradha Kumarasinghe, Melina Musfeldt, Christian Fiedler, Hendrik Lehnert, Jens-Uwe Marquardt
Published 2020-06-01

Changes in uPA, PAI-1, and TGF-β Production during Breast Cancer Cell Interaction with Human Mesenchymal Stroma/Stem-Like Cells (MSC)

by Catharina Melzer, Juliane von der Ohe, Hannah Otterbein, Hendrik Ungefroren, Ralf Hass
Published 2019-05-01

Correction: Characterization of Spontaneous and TGF-β-Induced Cell Motility of Primary Human Normal...

by Katharina Mandel, Daniel Seidl, Dirk Rades, Hendrik Lehnert, Frank Gieseler, Ralf Hass, Hendrik Ungefroren
Published 2013-01-01

RAC1B Suppresses TGF-β-Dependent Chemokinesis and Growth Inhibition through an Autoregulatory Feed-Forward Loop Involving PAR2 and ALK5

by Hannah Otterbein, Koichiro Mihara, Morley D. Hollenberg, Hendrik Lehnert, David Witte, Hendrik Ungefroren
Published 2019-08-01

Pluripotency gene expression and growth control in cultures of peripheral blood monocytes during their conversion into programmable cells of monocytic origin (PCMO): evidence for a regulatory role of autocrine activin and TGF-β.

by Hendrik Ungefroren, Ayman Hyder, Hebke Hinz, Stephanie Groth, Hans Lange, Karim M Fawzy El-Sayed, Sabrina Ehnert, Andreas K Nüssler, Fred Fändrich, Frank Gieseler
Published 2015-01-01