Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses

by Moon, James J., Suh, Heikyung, Bershteyn, Anna, Stephan, Matthias T., Liu, Haipeng, Huang, Bonnie, Sohail, Mashaal, Luo, Samantha, Ho Um, Soong, Khant, Htet, Goodwin, Jessica T., Ramos, Jenelyn, Chiu, Wah, Irvine, Darrell J
Published 2013

Design of Lipid Nanocapsule Delivery Vehicles for Multivalent Display of Recombinant Env Trimers in HIV Vaccination

by Pejawar-Gaddy, Sharmila, Kovacs, James M., Barouch, Dan H., Chen, Bing, Irvine, Darrell J
Published 2015

Enhancing Humoral Responses Against HIV Envelope Trimers via Nanoparticle Delivery with Stabilized Synthetic Liposomes

by Kulp, Daniel W., Mutafyan, Andrew A., Jones, Christopher A., Menis, Sergey, Georgeson, Erik, Kubitz, Mike, Zhang, Michael H., Melo, Mariane B., Silva, Murillo, Yun, Dong Soo, Schief, William R., Tokatlian, Talar, Irvine, Darrell J
Published 2019

Active targeting of chemotherapy to disseminated tumors using nanoparticle-carrying T cells

by Abraham, Wuhbet, Zheng, Yiran, Huang, Bonnie, Bustamante Lopez, Sandra C, Irvine, Darrell J, Luo, Samantha
Published 2017

Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction

by Moon, James J., Suh, Heikyung, Li, Adrienne Victoria, Ockenhouse, Christian F., Yadava, Anjali, Irvine, Darrell J
Published 2012

Liposomal vaccines incorporating molecular adjuvants and intrastructural T-cell help promote the immunogenicity of HIV membrane-proximal external region peptides

by Kim, Mikyung, Reinherz, Ellis L., Abraham, Wuhbet, Hanson, Melissa Catherine, Liu, Haipeng, Szeto, Gregory, Irvine, Darrell J, Chen, Stephanie H., Crespo, Monica P.
Published 2017

Nanoparticulate STING agonists are potent lymph node-targeted vaccine adjuvants

by Crespo, Monica P., Abraham, Wuhbet, Chen, Stephanie H., Mueller, Stefanie, Moynihan, Kelly Dare, Melo, Mariane Bandeira, Irvine, Darrell J, Szeto, Gregory, Hanson, Melissa Catherine
Published 2015

High Avidity CD8+ T Cells Efficiently Eliminate Motile HIV-Infected Targets and Execute a Locally Focused Program of Anti-Viral Function

by Foley, Maria Hottelet, Forcier, Talitha L., McAndrew, Elizabeth G., Gonzalez, Michael, Chen, Huabiao, Juelg, Boris, Walker, Bruce D., Irvine, Darrell J
Published 2014

Generation of Long-Lived Bone Marrow Plasma Cells Secreting Antibodies Specific for the HIV-1 gp41 Membrane-Proximal External Region in the Absence of Polyreactivity

by Donius, Luke R., Cheng, Yuxing, Choi, Jaewon, Sun, Zhen-Yu J., Marquez, Susanna, Uduman, Mohammed, Kleinstein, Steven H., Reinherz, Ellis L., Kim, Mikyung, Hanson, Melissa Catherine, Zhang, Michael H, Irvine, Darrell J, Love, John C, Gierahn, Todd Michael
Published 2017

Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers

by Pauthner, Matthias G., Nkolola, Joseph P., Havenar-Daughton, Colin, Murrell, Ben, Reiss, Samantha M., Bastidas, Raiza, Prévost, Jérémie, Nedellec, Rebecca, Bredow, Benjamin von, Abbink, Peter, Cottrell, Christopher A., Kulp, Daniel W. K, Tokatlian, Talar, Nogal, Bartek, Bianchi, Matteo, Li, Hui, Lee, Jeong Hyun, Butera, Salvatore T., Evans, David T., Hangartner, Lars, Finzi, Andrés, Wilson, Ian A., Wyatt, Richard T., Irvine, Darrell J., Irvine, Darrell J, Schief, William R., Ward, Andrew B., Sanders, Rogier W., Crotty, Shane, Shaw, George M., Barouch, Dan H., Burton, Dennis R.
Published 2020

T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity

by Schmid, Daniela, Park, Chun Gwon, Hartl, Christina A., Subedi, Nikita, Cartwright, Adam N., Puerto, Regina Bou, Maiarana, James, Freeman, Gordon J., Wucherpfennig, Kai W., Goldberg, Michael S., Zheng, Yiran, Irvine, Darrell J
Published 2018

A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton

by Janssen, Erin, Tohme, Mira, Hedayat, Mona, Leick, Marion, Ramesh, Narayanaswamy, Massaad, Michel J., Ullas, Sumana, Azcutia, Veronica, Goodnow, Christopher C., Randall, Katrina L., Qiao, Qi, Wu, Hao, Al-Herz, Waleed, Cox, Dianne, Hartwig, John, Luscinskas, Francis W., Geha, Raif S., Kumari, Sudha, Irvine, Darrell J
Published 2017

Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches

by Boopathy, Archana V, Tokatlian, Talar, Irvine, Darrell J
Published 2018

Resistance to PD1 blockade in the absence of metalloprotease-mediated LAG3 shedding

by Andrews, Lawrence P, Somasundaram, Ashwin, Moskovitz, Jessica M, Szymczak-Workman, Andrea L, Liu, Chang, Cillo, Anthony R, Lin, Huang, Normolle, Daniel P, Moynihan, Kelly Dare, Taniuchi, Ichiro, Irvine, Darrell J, Kirkwood, John M, Lipson, Evan J, Ferris, Robert L, Bruno, Tullia C, Workman, Creg J, Vignali, Dario AA
Published 2021

Histone Deacetylase Inhibitors Impair the Elimination of HIV-Infected Cells by Cytotoxic T-Lymphocytes

by Jones, Richard Bradley, O'Connor, Rachel, Mueller, Stefanie, Foley, Maria Hottelet, Karel, Dan, Lichterfeld, Mathias, Kovacs, Colin, Ostrowski, Mario A., Trocha, Alicja, Walker, Bruce D., Szeto, Gregory, Irvine, Darrell J
Published 2014

CD4+ T cell-dependent and CD4+ T cell-independent cytokine-chemokine network changes in the immune responses of HIV-infected individuals

by Lauffenburger, Douglas A, Szeto, Gregory, Alter, Galit, Irvine, Darrell J, Arnold, Kelly B.
Published 2017

A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4⁺ T-Cells to Recognition by Cytotoxic T-Lymphocytes

by O'Connor, Rachel, Rimpel, Katherine, Sloan, Derek D., Karel, Dan, Wong, Hing C., Jeng, Emily K., Thomas, Allison S., Whitney, James B., Lim, So-Yon, Kovacs, Colin, Benko, Erika, Karandish, Sara, Huang, Szu-Han, Buzon, Maria J., Lichterfeld, Mathias, Irrinki, Alivelu, Murry, Jeffrey P., Tsai, Angela, Yu, Helen, Geleziunas, Romas, Trocha, Alicja, Ostrowski, Mario A., Walker, Bruce D., Jones, Richard Bradley, Mueller, Stefanie, Irvine, Darrell J
Published 2017