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2“... is the potential to predict tumour response based on the profiling of enzymes involved in the bioreductive...”
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3by Ingram, N., McVeigh, L.E., Abou-Saleh, R.H., Maynard, J., Peyman, S.A., McLaughlan, J.R., Fairclough, M., Marston, G., Valleley, E.M.A., Jimenez-Macias, J.L., Charalambous, A., Townley, W., Haddrick, M., Wierzbicki, A., Wright, A., Volpato, M., Simpson, P.B., Treanor, D.E., Thomson, N.H., Loadman, Paul M., Bushby, R.J., Johnson, B.R.G., Jones, P.F., Evans, T., Freear, S., Markham, A.F., Evans, S.D., Coletta, P.L.Get full text
Published 2020
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5by Isambert, N., Campone, M., Bourbouloux, E., Drouin, M., Major, A., Yin, W., Loadman, Paul M., Capizzi, R., Grieshaber, C., Fumoleau, P.Subjects: “...Anti-tumour activity...”
Published 2010
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6by Atkinson, S.J., Loadman, Paul M., Sutton, Chris W., Patterson, Laurence H., Clench, M.R.“... to sensitise tumours to existing chemo- and radiotherapy treatments. In this study the distribution of AQ4N...”
Published 2010
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8by Gill, Jason H., Kirwan, Ian G., Seargent, Jill M., Martin, Sandie W., Tijani, S., Anikin, V.A., Mearns, A.J., Bibby, Michael C., Anthoney, Alan, Loadman, Paul M.Subjects: “...Tumour Markers...”
Published 2009
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10by Djidja, M-C., Francese, S., Loadman, Paul M., Sutton, Chris W., Scriven, P., Claude, E., Snel, M.F., Franck, J., Salzet, M., Clench, M.R.Subjects: “...Tumour xenograft...”
Published 2010
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11by Basu, Saurajyoti, Brown, John E., Flannigan, G. Michael, Gill, Jason H., Loadman, Paul M., Martin, Sandie W., Naylor, Brian, Puri, Rajiv, Scally, Andy J., Seargent, Jill M., Shah, Tariq K., Phillips, Roger M.“... expression was detected in NQO1*2/*2 tumours. A broad spectrum of NQO1 protein expression existed in tumours...”
Published 2014
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12by Guo, Xiaoxiao, Elkashelf, Sara M., Loadman, Paul M., Patterson, Laurence H., Falconer, Robert A.“...-embryogenesis, it is also re-expressed in a number of tumours of neuroendocrine origin. It plays important roles...”
Published 2019
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13by Atkinson, Jennifer M., Gill, Jason H., Loadman, Paul M., Martin, Sandie W., Pennington, J., Anikin, V.A., Mearns, A.J., Edwards, D.R.“... membrane-type MMPs (MT-MMPs), in human tumours has potential diagnostic, prognostic and therapeutic...”
Published 2009
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14by Phillips, Roger M., Loadman, Paul M., Maitland, Derek J., Shnyder, Steven D., Jaffar, M., Steans, Gillian, Cooper, Patricia A., Race, Amanda D., Patterson, A.V., Stratford, I.J.“... studies in non-tumour-bearing mice in vivo (at the maximum soluble dose of 60 mg kg¿1 administered...”
Published 2009
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15by Evans, C.J., Phillips, Roger M., Jones, P.F., Loadman, Paul M., Sleeman, B.D., Twelves, Christopher J., Smye, S.W.“...no === Inadequate drug delivery to tumours is now recognised as a key factor that limits...”
Published 2010
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16by Jove, M., Spencer, Jade A., Hubbard, M.E., Holden, E.C., O'Dea, R.D., Brook, B.S., Phillips, Roger M., Smye, S.W., Loadman, Paul M., Twelves, C.J.“...Yes === Adequate drug distribution through tumours is essential for treatment to be effective...”
Published 2019
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17by Steward, W.P., Middleton, M., Benghiat, A., Loadman, Paul M., Hayward, C., Walter, S., Ford, S., Halbert, G., Patterson, Laurence H., Talbot, D.“... levels were measured after the first dose. At 447 mg/m2, biopsies of tumour and normal tissue were taken...”
Published 2009
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18“... decades. Their exquisite potency, unique mechanism of action, and efficacy in multidrug-resistant tumour...”
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19“..., with ATR inhibitors having shown anti-tumour activity not just monotherapies, but also in potentiating...”
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20by Guo, Xiaoxiao, Malcolm, Jodie R., Ali, Marrwa M., Ribeiro Morais, Goreti, Shnyder, Steven D., Loadman, Paul M., Patterson, Laurence H., Falconer, Robert A.“... plays an important role in tumour metastasis. While assays are available to assess polyST enzyme...”
Published 2020
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