Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1

by Ryan, Jeremy A., Letai, Anthony, Jenson, Justin Michael, Grant, Robert A., Keating, Amy E.
Published 2018

Combinatorial bZIP dimers display complex DNA-binding specificity landscapes

by Rodriguez-Martinez, Jose A., Bhimsaria, Devesh, Ansari, Aseem Z., Reinke, Aaron Wade, Keating, Amy E.
Published 2017

Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway

by Depoil, David, Martinelli, Roberta, Judokusumo, Edward, Carmona, Guillaume, Kam, Lance C., Carman, Christopher V., Burkhardt, Janis K., Dustin, Michael L., Gertler, Frank, Kumari, Sudha, Irvine, Darrell J
Published 2015

Small molecule inhibition of apicomplexan FtsH1 disrupts plastid biogenesis in human pathogens

by Amberg-Johnson, Katherine, Ganesan, Suresh M., Lorenzi, Hernan A., Niles, Jacquin C., Yeh, Ellen, Hari, Sanjay B., Sauer, Robert T.
Published 2018

Discovery and validation of sub-threshold genome-wide association study loci using epigenomic signatures

by Wang, Xinchen, Rizki, Gizem, Mills, Robert, de Wit, Elzo, Subramanian, Vidya, Nguyen, Xinh-Xinh, Ye, Jiangchuan, Leyton-Mange, Jordan, van der Harst, Pim, de Laat, Wouter, Newton-Cheh, Christopher, Kellis, Manolis, Tucker, Nathan R., Krijger, Peter H. L., Bartell, Eric R., Dolmatova, Elena V., Ellinor, Patrick T., Milan, David J., Boyer, Laurie Ann
Published 2016

The kinetics of pre-mRNA splicing in the Drosophila genome and the influence of gene architecture

by Henriques, Telmo, McCue, Kayla, Burkholder, Adam, Adelman, Karen, Pai, Athma A., Burge, Christopher B
Published 2018

Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs

by Van de Kooij, Bert, Creixell Morera, Pau, Van Vlimmeren, Anne Elise, Joughin, Brian Alan, Yaffe, Michael B
Published 2020