controlled study nonhuman Article 13 simulation 8 Animals 6 Computational Biology 6 animal 6 animal experiment 6 biology 6 chemistry 6 Computer Simulation 5 biological model 5 computer simulation 5 male 5 physiology 5 Molecular Structure 4 animal tissue 4 chemical structure 4 in vivo study 4 Anti-Bacterial Agents 3 Male 3 Models, Neurological 3 antiinfective agent 3 drug formulation 3 human 3 mouse 3 procedures 3 process optimization 3 stochastic model 3 synthesis 3