down regulation female Article 46 human 44 controlled study 41 Humans 36 male 36 genetics 35 Female 33 upregulation 33 adult 32 unclassified drug 25 gene expression 24 Male 22 gene expression regulation 22 metabolism 22 major clinical study 21 human tissue 19 human cell 18 pathology 18 middle aged 17 aged 16 receiver operating characteristic 16 Middle Aged 15 blood 15 Gene Expression Regulation, Neoplastic 14 gene expression profiling 13 microRNA 12 nonhuman 12 protein expression 12