Showing 1 - 20 results of 24 for search '"TGF-β"', query time: 0.35s Refine Results
  1. 1
    Role of TGF-β/Smad signaling in pulmonary inflammation and fibrosis.
    Published 2013
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  2. 2
    Role of TGF β/Smad3 Signaling in T Cell- Mediated Glomerulonephritis
    Published 2016
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  3. 3
    Mechanisms of angiotensin II-mediated kidney injury: role of TGF-β/Smad signalling.
    Published 2012
    “...血管紧张素II(Ang II)在慢性肾脏病中起重要的致病作用，尽管体外研究证实TGF-β/Smad3起正调控，Smad7起负调控作用，但Smad3在Ang II 诱导的肾脏损害中的作用仍不清楚。因此...”
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  4. 4
    Combination of Asiatic Acid and Naringenin Inhibits Tumor Progression by Rebalancing TGF-β/Smad Signaling
    Published 2016
    “...转化生长因子(TGFβ)在腫瘤發生的早期階段通過抑制細胞增殖和誘導細胞凋亡而起著重要的保護性作用。然而，在後期階段，腫瘤細胞逐漸衍生出逃逸TGFβ腫瘤抑制的作用，甚至重塑TGFβ效應使其利於腫瘤的...”
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  5. 5
    Epigenetic Disruption of BMP7 as a Tumor Suppressor in Human Cancers
    Published 2016
    “...惡性腫瘤本質上是一種從遺傳學和表觀遺傳學上發生改變的疾病。這些改變導致多重信號通路的改變，從而主導腫瘤的發生和發展。在其中，轉化生長因子beta 家族(TGF-β)信號通路是一個在腫瘤中具有多重功能...”
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  6. 6
    Dissection of TGF-beta/Smads in the renal inflammation and fibrosis.
    Published 2012
    “...目的： 转化生长因子－1（TGF-β1）通过与II型受体结合而引起I型受体活化，进一步激活其下游信号分子蛋白Smad2 和Smad3，它们与Smad4（Co-Smad）结合后形成Smad复合体并发生...”
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  7. 7
    High Risk HPV Oncogene E7 Upregulates miR-182 through TGF-¦Â/Smad Pathway
    Published 2016
    “...-PCR/Weston-blot檢測發現，過表達/沉默高危型HPVE7基因可引起TGF-β和miR-182的上調/下調，並且TGF-β能夠引起miR-182的表達變化(P<0.05)，并通過免疫組織化學...”
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  8. 8
    The functional role of MicroRNA-21 in renal fibrosis.
    Published 2012
    “...目的： === TGF-β/Smad信号通路在慢性肾脏纤维化疾病中有着重要的作用。大量研究证实Smad3在TGF-β/Smad信号介导的肾脏纤维化过程中发挥着关键的作用，但TGF-β/Smad3这一...”
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  9. 9
    The functional role of microRNA-433-Azin1 axis in renal fibrosis.
    Published 2014
    “...慢性腎髒病這一以終末期腎髒病（ESRD）為結局的疾病腎臟損傷和進展的主要病理特徵。現已確立转化生长因子β/Smads 信号蛋白（TGF-β/Smad）在腎臟纖維化發病機制中具有主要的作用。在過去近20年...”
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  10. 10
    Role of Smad4 in Mouse Abdominal Wall Development
    Published 2016
    “...發育的基因調控一直是撲朔迷離的。研究指出，敲除TGF-β訊號通路的介體會導致腹壁發育不良，故我們用En1-Cre去條件性敲除小鼠皮膚中的Smad4，用以研究TGF-β在腹壁發育中的功能。 === 我們的...”
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  11. 11
    Functional role of Smad3 in mouse embryonic stem cell self-renewal, differentiation and teratoma growth.
    Published 2014
    “...TGF-β/Activin/Nodal 信號通路調節了許多重要的細胞生物學過程,例如,細胞分裂,增殖,分化,遷移和衰老凋亡。此外,它也在胚胎髮育,損傷修復,腫瘤發生,組織纖維化,糖尿病發生及其免疫...”
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  12. 12
    Bone marrow-derived macrophage myofibroblast transition (MMT) in renal fibrosis.
    Published 2012
    “...⁺collagen I⁺ fibrocytes的关系。最后，通过观察GFP⁺Smad3⁻/⁻骨髓嵌合体小鼠UUO模型肾纤维化程度和TGF-β1刺激下TGF-β受体II或Smad3敲除的骨髓巨噬细胞MMT的不同进一步...”
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  13. 13
    The role of CFTR in epithelial-mesenchymal transition.
    Published 2012
    “... HIF-1 和 TGF-β 的反向調節。另外，CFTR 的表達和功能被證實參與 EMT 相關信號分子 Wnt 和 NF-κB活性的調節。基於上述發現，本研究旨在闡述 CFTR 與 EMT 的相關性...”
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  14. 14
    Genetic Engineering a TGF-beta1 Tolerant Human Natural Killer Cell Line for Effective Anticancer Immunotherapy
    Published 2016
    “...啟動子活性促進IFN-ɣ的表達。因此，我們可以推斷，在腫瘤微環境中癌症細胞可能利用TGFβ1/Smad3/E4BP4這條信號傳遞軸來逃避NK細胞介導的免疫殺傷效應。 === 除此之外，我們通過細胞因子...”
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  15. 15
    The Role of C- Reactive Protein in Type 2 Diabetes and Diabetic Nephropathy
    Published 2016
    “...进一步加重，表现为肾脏Ⅰ型和Ⅳ型胶原的过度沉积。通过对CRP在体内、体外的分子病例机制和信号转导通路研究，我们发现CRP介导的糖尿病肾脏病变与CRP受体（CD32b）表达上调以及 NF-κB, TGF-β...”
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  16. 16
    Transcriptional and proteomic study of brain and reproductive organ-expressed (BRE) gene in human umbilical cord perivascular stem cells.
    Published 2012
    “...5和FOXO1A等基因的表達顯著下調。 另外，BRE基因的沉默能夠影響表觀遺傳調控基因以及TGF-β 信號通路組成部件的表達，而TGF -β 信號通路是維持幹細胞自我更新的重要通路。 這些結果提示...”
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  17. 17
    Characterization of long non-coding RNA H19 in epithelial to mesenchymal transition: 長非編碼RNA H19在上皮間充質轉化中的功能探究
    Published 2014
    “... that after treatment of TGF-β1, one of the most widely used EMT inducers, H19 presented dramatic increase...”
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  18. 18
    The role of Dragon (RGMb) in kidney injury
    Published 2014
    “... expression, but did not affect epithelial-to-mesenchymal transition (EMT) induced by TGF-β1 in mouse inner...”
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  19. 19
    Studies of the control of VEGF expression in testicular cell lines and in the testis.
    Published 1999
    “....92 === Chapter 3.12 --- Effect of bFGF and TGF- β1 on VEGF expression in TM3 cells --- p.102...”
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  20. 20
    Molecular characterization of human adipose tissue-derived stem cells.
    Published 2007
    “... --- p.33 === Chapter 1.4.3 --- Signaling Pathway of the TGF-β Superfamily --- p.34 === Chapter 1.5...”
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