human cell metabolism human 43 Article 42 controlled study 39 Humans 36 Animals 29 animal 29 genetics 27 nonhuman 27 animal experiment 25 animal model 24 mouse 24 unclassified drug 23 in vitro study 21 animal tissue 20 in vivo study 18 male 18 cell proliferation 16 pathology 16 Cell Line, Tumor 15 Male 15 Mice 15 female 15 tumor cell line 15 gene expression 14 gene expression regulation 13 signal transduction 13 Cell Proliferation 12 Female 12