DNA sequence 4 High-Throughput Nucleotide Sequencing 4 Mapping Sequence Analysis, DNA high throughput sequencing 4 Software 3 software 3 Algorithms 2 DNA 2 Humans 2 Next-generation sequencing 2 Sequence Alignment 2 Simulated datasets 2 State of the art 2 algorithm 2 human 2 sequence alignment 2 Alignment 1 Alignment-free sequence comparison 1 Alkylation 1 Bacterial strains 1 Bayes Theorem 1 Bayes theorem 1 Bayesian 1 Bisulfite 1 Computational problem 1 Conserved regions 1 Contigs 1 Critical steps 1 DNA Methylation 1