Compounds from an Unbiased Chemical Screen Reverse Both Er-to-Golgi Trafficking Defects and Mitochondrial Dysfunction in Parkinson's Disease Models

by Su, Linhui Julie, Auluck, Pavan K., Outeiro, Tiago Fleming, Yeger-Lotem, Esti, Kritzer, Joshua A., Tardiff, Daniel F., Bell, George W., Fraenkel, Ernest, Lindquist, Susan, Strathearn, Katherine E., Liu, Fang, Cao, Songsong, Hamamichi, Shusei, Hill, Kathryn J., Caldwell, Kim A., Cooper, Antony A., Caldwell, Guy A., McCaffery, J. Michael, Rochet, Jean-Christophe
Published 2011

Cyclin-G-associated kinase modifies alpha-synuclein expression levels and toxicity in Parkinson's disease: results from the GenePD Study

by Dumitriu, Alexandra, Pacheco, Chris D., Wilk, Jemma B., Strathearn, Katherine E., Latourelle, Jeanne C., Goldwurm, Stefano, Pezzoli, Gianni, Rochet, Jean-Christophe, Lindquist, Susan, Myers, Richard H.
Published 2011

Detecting Motor Impairment in Early Parkinson's Disease via Natural Typing Interaction...

by Arroyo Gallego, Teresa, Ledesma-Carbayo, María J, Butterworth, Ian, Matarazzo, Michele, Montero-Escribano, Paloma, Puertas-Martín, Verónica, Gray, Martha L., Giancardo, Luca, Sanchez Ferro, Alvaro
Published 2020

Identification and Rescue of  -Synuclein Toxicity in Parkinson Patient-Derived Neurons

by Chung, Chee Yeun, Khurana, Vikram, Auluck, Pavan K., Tardiff, Daniel F., Mazzulli, Joseph R., Soldner, Frank, Baru, Valeriya, Lou, Yali, Freyzon, Yelena, Cho, Sukhee, Muffat, Julien, Mitalipova, Maisam, Pluth, Michael D., Jui, Nathan T., Schule, Birgitt, Lippard, Stephen J., Tsai, Li-Huei, Krainc, Dimitri, Jaenisch, Rudolf, Lindquist, Susan, Mungenast, Alison, Buchwald, Stephen Leffler
Published 2015

Algorithm for Turning Detection and Analysis Validated under Home-Like Conditions in Patients with Parkinson?s Disease and Older Adults using a 6 Degree-of-Freedom Inertial Measurement Unit at the Lower Back

by Pham, Minh H., Elshehabi, Morad, Haertner, Linda, Heger, Tanja, Hobert, Markus A., Faber, Gert S., Salkovic, Dina, Ferreira, Joaquim J., Berg, Daniela, Maetzler, Walter, van Dieen, Jaap H., Sanchez Ferro, Alvaro
Published 2017

Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression

by Soldner, Frank, Stelzer, Yonatan, Abraham, Brian J., Latourelle, Jeanne C., Barrasa, M. Inmaculada, Goldmann, Johanna, Myers, Richard H., Jaenisch, Rudolf, Shivalila, Chikdu Shakti, Young, Richard A.
Published 2017

Cell type-specific plasticity of striatal projection neurons in parkinsonism and L-DOPA-induced dyskinesia

by Fieblinger, Tim, Graves, Steven M., Sebel, Luke E., Alcacer, Cristina, Plotkin, Joshua L., Gertler, Tracy S., Chan, C. Savio, Heiman, Myriam, Greengard, Paul, Cenci, M. Angela, Surmeier, D. James
Published 2016

Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations

by Soldner, Frank, Hockemeyer, Dirk, Gao, Qing, Alagappan, Raaji, Khurana, Vikram, Golbe, Lawrence I, Myers, Richard H., Lindquist, Susan, Guschin, Dmitry, Fong, Lauren K, Vu, B. Joseph, Meng, Xiangdong, Urnov, Fyodor D, Rebar, Edward J, Gregory, Philip D., Zhang, H. Steve, Jaenisch, Rudolf, Laganiere, Josee, Zhang, Lei, Ph. D Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, fl. 2014, Cheng, Albert Wu
Published 2014

Conversations With Dr. Oleh Hornykiewicz, Founding Father of the Dopamine Era in Parkinson's: How Do You Wish to Be Remembered?

by Schlossmacher, Michael G., Graybiel, Ann M
Published 2021

Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment

by Fanning, Saranna, Haque, Aftabul, Imberdis, Thibaut, Baru, Valeriya, Barrasa, M. Inmaculada, Nuber, Silke, Termine, Daniel, Ramalingam, Nagendran, Ho, Gary P.H, Noble, Tallie, Sandoe, Jackson, Lou, Yali, Landgraf, Dirk, Freyzon, Yelena, Newby, Gregory, Soldner, Frank, Terry-Kantor, Elizabeth, Kim, Tae-Eun, Hofbauer, Harald F., Becuwe, Michel, Jaenisch, Rudolf, Pincus, David, Clish, Clary B., Walther, Tobias C., Farese, Robert V., Srinivasan, Supriya, Welte, Michael A., Kohlwein, Sepp D., Dettmer, Ulf, Lindquist, Susan, Selkoe, Dennis
Published 2020

Using point process models to determine the impact of visual cues on basal ganglia activity and behavior of Parkinson's patients

by Sarma, Sridevi V., Eden, Uri T., Cheng, Ming L., Williams, Ziv, Eskandar, Emad, Brown, Emery N.
Published 2010

Using point process models to compare neural spiking activity in the nucleus of Parkinson's patients and a healthy primate

by Sarma, Sridevi V., Eden, Uri T., Cheng, Ming L., Williams, Ziv M., Hu, Rollin, Eskandar, Emad, Brown, Emery N.
Published 2012

Using Point Process Models to Compare Neural Spiking Activity in the Subthalamic Nucleus of Parkinsons Patients and a Healthy Primate

by Sarma, Sridevi V., Eden, Uri T., Cheng, Ming L., Williams, Ziv M., Hu, Rollin, Eskandar, Emad, Brown, Emery N.
Published 2011

Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats

by Jaenisch, Rudolf, Hargus, Gunnar, Cooper, Oliver, Deleidi, Michela, Levy, Adam, Lee, Kristen N., Marlow, Elizabeth, Yow, Alyssa, Soldner, Frank, Hockemeyer, Dirk, Hallett, Penelope J., Osborn, Teresia, Isacson, Ole
Published 2014

Isogenic Human iPSC Parkinson's Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription

by Ryan, Scott D, Dolatabadi, Nima, Chan, Shing Fai, Zhang, Xiaofei, Akhtar, Mohd Waseem, Parker, James, Soldner, Frank, Sunico, Carmen R, Nagar, Saumya, Talantova, Maria, Lopez, Kevin, Nutter, Anthony, Shan, Bing, Molokanova, Elena, Zhang, Yaoyang, Han, Xuemei, Nakamura, Tomohiro, Masliah, Eliezer, Yates, John R, Nakanishi, Nobuki, Andreyev, Aleksander Y, Okamoto, Shu-ichi, Jaenisch, Rudolf, Ambasudhan, Rajesh, Lipton, Stuart A, Lee, Brian 1975-
Published 2016

Parkinson's Patients' Tolerance for Risk and Willingness to Wait for Potential Benefits of Novel...

by Hauber, Brett, Mange, Brennan, Zhou, Mo, Chaudhuri, Shomesh, Benz, Heather L, Caldwell, Brittany, Ruiz, John P, Saha, Anindita, Ho, Martin, Christopher, Stephanie, Bardot, Dawn, Sheehan, Margaret, Donnelly, Anne, McLaughlin, Lauren, Gwinn, Katrina, Lo, Andrew, Sheldon, Murray
Published 2022

Sirtuin deacetylases in neurodegenerative diseases of aging

by Herskovits, A. Zara, Guarente, Leonard Pershing
Published 2014

Neurophysiological Vocal Source Modeling for Biomarkers of Disease

by Ciccarelli, Gregory A., Quatieri, Thomas F., Ghosh, Satrajit S.
Published 2016

DEGAS: de novo discovery of dysregulated pathways in human diseases

by Ulitsky, Igor, Shamir, Ron, Krishnamurthy, Akshay, Karp, Richard M.
Published 2011

Caldag-Gefi Down-Regulation in the Striatum as a Neuroprotective Change in Huntington's Disease.

by Dunn, Denise E., Merali, Farhan I., Woodman, Ben, Yim, Michael, Borkowska, Anna E., Frosch, Matthew P., Bates, Gillian P., Lo, Donald C., Crittenden, Jill R, Housman, David E, Graybiel, Ann M
Published 2011