(Chymo)trypsin-like proteinases 3C-like protease, SARS coronavirus 1 3C-like proteinase, SARS-CoV-2 1 Amino Acid Substitution 1 Autolysis 1 COVID-19 1 Catalytic tetrad 1 Coronavirus 3C Proteases 1 Humans 1 Interdomain loop 1 Mutation, Missense 1 Protein Domains 1 SARS Virus 1 SARS coronavirus 1 SARS-CoV-2 1 Species Specificity 1 Structural catalytic core 1 Structure-Activity Relationship 1 amino acid substitution 1 chemistry 1 enzymology 1 genetics 1 human 1 missense mutation 1 protein domain 1 species difference 1 structure activity relation 1