Akt signaling Article 8 controlled study 7 down regulation 7 human 7 metabolism 7 protein expression 7 protein kinase B 7 signal transduction 7 Humans 6 Signal Transduction 6 genetics 5 male 5 mammalian target of rapamycin 5 phosphatidylinositol 3 kinase 5 upregulation 5 Animals 4 Phosphatidylinositol 3-Kinases 4 TOR Serine-Threonine Kinases 4 animal 4 human cell 4 in vitro study 4 protein function 4 protein phosphorylation 4 target of rapamycin kinase 4 MTOR protein, human 3 Proto-Oncogene Proteins c-akt 3 animal model 3 cell migration 3 cell proliferation 3