Article adult 45 female human 45 male middle aged Humans 44 Male 41 Middle Aged 41 genetics 41 Female 40 controlled study 38 unclassified drug 34 major clinical study 33 gene expression 30 gene expression regulation 30 pathology 28 Gene Expression Regulation, Neoplastic 26 human tissue 25 aged 24 metabolism 23 Aged 21 human cell 17 case control study 16 tumor marker 16 upregulation 16 Biomarkers, Tumor 15 down regulation 15 real time polymerase chain reaction 15 Case-Control Studies 14