Article female male unclassified drug human 43 Humans 42 adult 40 genetics 39 controlled study 38 Female 36 Male 36 major clinical study 34 middle aged 34 Middle Aged 32 gene expression 28 pathology 26 gene expression regulation 25 metabolism 22 human tissue 21 Gene Expression Regulation, Neoplastic 20 down regulation 20 upregulation 20 aged 19 microRNA 18 MicroRNAs 17 human cell 16 Aged 15 prognosis 15 case control study 14 receiver operating characteristic 14