Article real time polymerase chain reaction controlled study 46 human 42 genetics 40 Humans 38 gene expression 35 gene expression regulation 32 unclassified drug 31 metabolism 30 protein expression 27 adult 26 upregulation 26 male 24 female 23 down regulation 22 Female 21 Male 20 human tissue 20 Gene Expression Regulation, Neoplastic 19 human cell 19 middle aged 19 pathology 19 Middle Aged 18 Western blotting 18 nonhuman 18 major clinical study 17 microRNA 17 MicroRNAs 15 cell proliferation 15