Article chemistry 334 controlled study 255 nonhuman 200 human 177 unclassified drug 157 metabolism 152 Humans 150 Animals 90 animal 90 drug effect 80 genetics 77 male 73 procedures 66 Male 59 animal experiment 57 physical chemistry 56 in vitro study 52 human cell 51 pH 49 female 45 mouse 45 isolation and purification 44 plant extract 44 protein expression 42 chemical structure 40 animal tissue 39 Mice 38 Plant Extracts 38 animal model 38