Aging 1 Animals 1 Article 1 Blood-Brain Barrier 1 Blood–brain barrier CNS diseases 1 Cells, Cultured 1 Cellular Senescence 1 DNA 1 DNA damage response 1 DNA synthesis 1 Endothelial Cells 1 In vitro model 1 Ki 67 antigen 1 Mice 1 Models, Biological 1 Senescence 1 Western blotting 1 animal 1 animal cell 1 astrocyte 1 beta galactosidase 1 biological model 1 blood brain barrier 1 cell aging 1 cell culture 1 cell membrane permeability 1 cytology 1 endothelium cell 1 immunofluorescence assay 1