Canagliflozin Sodium-Glucose Transporter 2 Inhibitors 2 canagliflozin 2 Animals 1 Article 1 Basic Helix-Loop-Helix Transcription Factors 1 Diabetes Mellitus, Experimental 1 Diabetes Mellitus, Type 2 1 Diabetic Nephropathies 1 Fibrosis 1 Glucose 1 Glycated Hemoglobin A 1 Humans 1 Hypoglycemic Agents 1 Hypoxia 1 Hypoxia-Inducible Factor 1, alpha Subunit 1 India 1 Metformin 1 Mice 1 Mice, Transgenic 1 SGLT2 inhibitors 1 Sulfonylurea Compounds 1 Treatment Outcome 1 amputation 1 animal 1 antidiabetic agent 1 basic helix loop helix transcription factor 1 blindness 1 body mass 1 body weight 1