Article 2 Female Humans 2 Male 2 Middle Aged 2 adult 2 controlled study 2 female 2 gene expression 2 genetics 2 human 2 major clinical study 2 male 2 middle aged 2 real time polymerase chain reaction 2 Adult 1 Aged 1 B Raf kinase 1 BRAF 1 BRAF gene 1 BRAF protein, human 1 Biomarkers, Tumor 1 CTLA-4 Antigen 1 CTLA4 1 CTLA4 gene 1 CTLA4 protein, human 1 Case-Control Studies 1 Caucasian 1 Colorectal Neoplasms 1 Gene Expression 1