Humans human 221 receiver operating characteristic 170 Article 169 female 154 adult 145 male 144 controlled study 140 Female 124 major clinical study 118 Male 110 middle aged 97 Middle Aged 90 sensitivity and specificity 84 ROC Curve 80 Adult 68 aged 65 diagnostic test accuracy study 63 blood 57 procedures 57 Aged 52 area under the curve 48 pathology 47 genetics 46 biological marker 39 risk factor 39 prognosis 38 retrospective study 37 Case-Control Studies 36 Prognosis 36