Computation 1 Computational mutagenesis 1 Crystal structure 1 Diagnosis 1 Forecasting 1 Local environments 1 Machine learning Machine learning methods 1 Mutagenesis 1 Mutation 1 Protein Engineering 1 Protein Stability 1 Protein engineering 1 Protein stability 1 Protein structure 1 Proteins 1 Stability 1 Stability prediction 1 Structural differences 1 Structural information 1 Structural sensitivity 1 Thermodynamics 1 genetics 1 mutagenesis 1 protein 1 protein engineering 1 protein stability 1 thermodynamics 1