Article 1 COVID-19 1 Drug discovery 1 Mechanistic modeling Severe acute respiratory syndrome coronavirus 2 1 Signaling pathway 1 Systems biology 1 coronavirus disease 2019 1 downstream processing 1 gene expression 1 gene knockdown 1 human 1 inflammation 1 nonhuman 1 priority journal 1 signal transduction 1 systems biology 1 virus entry 1 virus infection 1